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C-reactive protein (CRP) by nephelometry

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of C-reactive protein, a protein produced by the liver in response to inflammation in your body.

Quick summary

["CRP helps identify inflammation, often used to monitor conditions like infections or autoimmune diseases."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
99401-2
Short code
CD19FMC7BM
Synonyms
Cells.CD19+FMC7+ NFr Mar
Category
chemistry
Sample
serum
Container
Heparinized bone marrow aspirate collected in sterile EDTA or sodium heparin tubes for flow cytometry; preserve in tissue culture medium if processing delayed.
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
0–120 years
Method
Flow cytometry using fluorescently labeled monoclonal antibodies (CD19 and FMC7) with multiparameter immunophenotyping
CPT
88184
SNOMED
444091008
Specimen volume
1-3 mL of bone marrow aspirate in anticoagulant tube; minimum 0.5 mL for flow cytometric analysis
Stability
Specimen should be processed within 24 hours of collection when stored at room temperature (18-25°C). Refrigerated storage (2-8°C) acceptable for up to 48 hours. Avoid freezing.
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
24–72 hours
Order
routine

C-reactive protein, often called CRP, is a substance that your liver produces when there is inflammation somewhere in your body. Measuring the level of this protein in your blood helps your doctor detect and monitor conditions that cause inflammation, such as infections, autoimmune diseases, and other chronic health problems.

C-reactive protein (CRP) is a marker produced by your liver when your body is fighting inflammation. It rises in response to infections, injuries, or conditions causing inflammation, such as arthritis or heart disease. This test helps doctors assess whether inflammation is present and guide treatment decisions.

Your doctor may order a C-reactive protein test if you have signs of an infection or an inflammatory condition, such as fever, pain, swelling, or general weakness. The test can also help track how well treatment is working for conditions like rheumatoid arthritis, lupus, inflammatory bowel disease, or a serious infection over time.

Your healthcare provider may order a CRP test to check for inflammation, diagnose conditions like infections, or monitor chronic diseases. It’s also used before surgeries or procedures to assess risk.

The test is done with a simple blood draw, usually from a vein in your arm. A healthcare provider will clean the skin, wrap a band around your upper arm, and use a small needle to collect a blood sample into a tube. The sample is then sent to a laboratory, and the entire process typically takes only a few minutes.

A small blood sample is taken from a vein, usually in your arm. The sample is sent to a lab where CRP levels are measured using nephelometry, a method that detects protein particles in the blood.

Higher-than-normal CRP levels usually mean there is inflammation in your body, which can come from infections, injuries, or chronic conditions such as arthritis or heart disease. The test does not show exactly where the inflammation is, so your doctor will interpret your results together with your symptoms, physical exam, and other laboratory tests.

Results show CRP levels, which can help determine the presence or severity of inflammation. Higher levels may indicate active inflammation, while lower levels suggest it’s under control. Your doctor will interpret results in the context of your overall health and symptoms.

Reference range

Reference ranges vary by laboratory; results typically reported as percentage of total bone marrow cells or as absolute count. Normal CD19+ B-lymphocytes expressing FMC7 are typically a minor subpopulation in healthy bone marrow. Consult laboratory-specific reference intervals.N/A

Specimen: serum

No special preparation required. Inform the ordering physician of any recent medications (e.g., corticosteroids, chemotherapy, immunosuppressants) or recent transfusions that may affect bone marrow cellularity. Bone marrow aspiration is performed by a qualified healthcare provider under sterile technique.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

CRP (Nephelometry)

Frequently asked questions

How often will I need this test?
If your C-reactive protein level is high, it means your body has inflammation, but the test alone does not reveal the cause. Your doctor may order additional tests or repeat the CRP measurement to find the source. Many causes, from minor infections to more serious conditions, are treatable, so it is important to follow up with your healthcare provider.
High CRP levels may signal infections, autoimmune diseases, or other inflammatory conditions. Your doctor will discuss next steps, which could include further testing, lifestyle changes, or treatment adjustments.
In most cases, you can eat and drink normally before a C-reactive protein blood test, because fasting is usually not required. However, if your blood sample will also be used for other tests at the same time, your doctor may ask you to avoid food or certain drinks for several hours. Always follow the specific instructions your healthcare team gives you.
Typically, no special preparation is needed. However, always follow your doctor’s instructions, as some conditions (like fasting) may affect results.
The blood draw may cause slight discomfort, but it’s usually over quickly. Most people feel minimal pain or a pinch at the injection site.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy