C-reactive protein (CRP) by nephelometry
This test measures the level of C-reactive protein, a protein produced by the liver in response to inflammation in your body.
["CRP helps identify inflammation, often used to monitor conditions like infections or autoimmune diseases."]
Key facts at a glance
- LOINC
- 99401-2
- Short code
- CD19FMC7BM
- Synonyms
- Cells.CD19+FMC7+ NFr Mar
- Category
- chemistry
- Sample
- serum
- Container
- Heparinized bone marrow aspirate collected in sterile EDTA or sodium heparin tubes for flow cytometry; preserve in tissue culture medium if processing delayed.
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 0–120 years
- Method
- Flow cytometry using fluorescently labeled monoclonal antibodies (CD19 and FMC7) with multiparameter immunophenotyping
- CPT
- 88184
- SNOMED
- 444091008
- Specimen volume
- 1-3 mL of bone marrow aspirate in anticoagulant tube; minimum 0.5 mL for flow cytometric analysis
- Stability
- Specimen should be processed within 24 hours of collection when stored at room temperature (18-25°C). Refrigerated storage (2-8°C) acceptable for up to 48 hours. Avoid freezing.
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 24–72 hours
- Order
- routine
C-reactive protein, often called CRP, is a substance that your liver produces when there is inflammation somewhere in your body. Measuring the level of this protein in your blood helps your doctor detect and monitor conditions that cause inflammation, such as infections, autoimmune diseases, and other chronic health problems.
C-reactive protein (CRP) is a marker produced by your liver when your body is fighting inflammation. It rises in response to infections, injuries, or conditions causing inflammation, such as arthritis or heart disease. This test helps doctors assess whether inflammation is present and guide treatment decisions.
Your doctor may order a C-reactive protein test if you have signs of an infection or an inflammatory condition, such as fever, pain, swelling, or general weakness. The test can also help track how well treatment is working for conditions like rheumatoid arthritis, lupus, inflammatory bowel disease, or a serious infection over time.
Your healthcare provider may order a CRP test to check for inflammation, diagnose conditions like infections, or monitor chronic diseases. It’s also used before surgeries or procedures to assess risk.
The test is done with a simple blood draw, usually from a vein in your arm. A healthcare provider will clean the skin, wrap a band around your upper arm, and use a small needle to collect a blood sample into a tube. The sample is then sent to a laboratory, and the entire process typically takes only a few minutes.
A small blood sample is taken from a vein, usually in your arm. The sample is sent to a lab where CRP levels are measured using nephelometry, a method that detects protein particles in the blood.
Higher-than-normal CRP levels usually mean there is inflammation in your body, which can come from infections, injuries, or chronic conditions such as arthritis or heart disease. The test does not show exactly where the inflammation is, so your doctor will interpret your results together with your symptoms, physical exam, and other laboratory tests.
Results show CRP levels, which can help determine the presence or severity of inflammation. Higher levels may indicate active inflammation, while lower levels suggest it’s under control. Your doctor will interpret results in the context of your overall health and symptoms.
Reference range
Reference ranges vary by laboratory; results typically reported as percentage of total bone marrow cells or as absolute count. Normal CD19+ B-lymphocytes expressing FMC7 are typically a minor subpopulation in healthy bone marrow. Consult laboratory-specific reference intervals.N/A
No special preparation required. Inform the ordering physician of any recent medications (e.g., corticosteroids, chemotherapy, immunosuppressants) or recent transfusions that may affect bone marrow cellularity. Bone marrow aspiration is performed by a qualified healthcare provider under sterile technique.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
CRP (Nephelometry)
Frequently asked questions
How often will I need this test?
High CRP levels may signal infections, autoimmune diseases, or other inflammatory conditions. Your doctor will discuss next steps, which could include further testing, lifestyle changes, or treatment adjustments.
Typically, no special preparation is needed. However, always follow your doctor’s instructions, as some conditions (like fasting) may affect results.
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy