Fibrinogen with D-Dimer Ratio (Blood Sample)
This test measures the balance between your blood’s ability to clot and the breakdown products of clots, which can help assess risks of bleeding or clotting disorders.
["Helps evaluate blood clotting health and potential risks of abnormal clotting or bleeding."]
Key facts at a glance
- LOINC
- 78235-9
- Short code
- PDGFRB FISH
- Synonyms
- Cells.PDGFRB rear/Cells cnt Bld/T FISH
- Category
- chemistry
- Sample
- whole-blood
- Container
- Sodium heparin (green-top) tube for blood; sterile RPMI transport medium for tissue/bone marrow specimens
- Units
- N/A
- Ref low
- 0
- Ref high
- 10
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 0–120 years
- Method
- Fluorescence In Situ Hybridization (FISH) with PDGFRB gene rearrangement probe set, typically using dual-color break-apart probes targeting the 5q32 chromosomal region; analyzed in 200 interphase nuclei or metaphase cells
- CPT
- 88271
- SNOMED
- 444068001
- Specimen volume
- 3-5 mL whole blood or 1-3 mL bone marrow aspirate; minimum 200 nucleated cells required for analysis
- Stability
- Whole blood/bone marrow stable for 24-48 hours at room temperature (20-25°C); 72 hours refrigerated (2-8°C); tissue samples should be processed within 24 hours
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 72–168 hours
- Order
- routine
What This Test Measures
Fibrinogen is a protein your body produces to help blood clot when injured. D-Dimer is a marker released when clots break down. This test compares their levels to identify whether clotting processes are active or suppressed.
Why It’s Done
Doctors may order this test if you have symptoms like excessive bruising, unexplained bleeding, or signs of blood clots (e.g., swelling, pain in limbs). It’s also used in conditions like deep vein thrombosis, pulmonary embolism, or certain cancers.
How It Works
A blood sample is taken, and lab tests measure fibrinogen and D-Dimer levels separately. The ratio helps determine whether clotting is more active (elevated D-Dimer) or if clotting factors are insufficient (low fibrinogen).
What to Expect Before or After
No special preparation is needed. You may feel slight discomfort from the needle, but it’s usually over quickly. Avoid strenuous activity for 24 hours post-test if you’re prone to bleeding.
Reference range
Negative (no PDGFRB gene rearrangement detected). Reference range reported as percentage of cells with abnormal signal pattern. Normal: <10% cells showing split or abnormal signal pattern. Positive: ≥10% cells with evidence of rearrangement.N/A
No special patient preparation required. Patients should inform their physician of all medications, recent blood transfusions, or bone marrow transplant history as these may affect test interpretation.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
A high D-Dimer ratio with normal fibrinogen may suggest active clotting (e.g., DVT, stroke). A low fibrinogen ratio with normal D-Dimer could indicate bleeding risks or liver disease affecting protein production. Always discuss results with your provider for personalized interpretation.
Short name
Fibrinogen/D-Dimer Ratio
Frequently asked questions
How long does it take to get results?
Can I eat or drink before this test?
Does this test replace other blood tests?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy