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Alpha-1 Antitrypsin (A1AT) Serum Protein Electrophoresis

Published: August 9, 2026Updated: August 16, 2026

This test measures the distribution of proteins in your blood using electrophoresis, focusing on Alpha-1 Antitrypsin, a protein that helps protect your lungs and liver from damage.

Quick summary

["This test helps identify abnormal protein patterns that may indicate genetic conditions affecting protein levels."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
81714-8
Short code
CENPA
Synonyms
CENP A Ab Ser Ql Line blot
Category
chemistry
Sample
serum
Container
Serum separator tube (SST) or red-top tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
line-blot
CPT
86235
SNOMED
164654009
Specimen volume
0.5-1 mL of serum
Stability
Stable for 7 days at 2-8°C; for longer storage, freeze at -20°C or below
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
24–72 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like chronic lung issues (such as emphysema), liver problems, or if they suspect a genetic disorder related to protein production. It can also be used to monitor known conditions affecting protein levels in the blood.

How the Test Works

A small blood sample is drawn, and the serum is separated. The sample is then placed in an electric field to separate proteins based on size and charge. The distribution of Alpha-1 Antitrypsin and other proteins is visualized on a gel or strip.

Sample Collection and Preparation

Blood is collected from a vein in your arm. The serum portion is prepared for analysis. This test does not require fasting.

What to Expect Before the Test

No special preparation is needed, but inform your provider about any medications or supplements you take, as they may affect results.

Reference range

Negative (antibody not detected)N/A

Specimen: serum

No special preparation required

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

A1AT Electrophoresis

Frequently asked questions

Alpha-1 Antitrypsin deficiency can lead to lung diseases like emphysema or liver diseases. Abnormal electrophoresis patterns may reveal low levels of Alpha-1 Antitrypsin or unusual protein distributions, guiding further genetic or medical evaluation.
This test helps diagnose or monitor conditions linked to abnormal protein patterns, such as hereditary protein disorders.
How long will it take to get results?
Results are typically available within a few days to a week, depending on lab processing times.
What does a low or high Alpha-1 Antitrypsin level mean?
Low levels may indicate a genetic disorder requiring further testing or management, while high levels may suggest conditions like chronic inflammation or certain liver diseases. Your provider will interpret results in the context of your overall health.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy