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Centromere Antibody Screening Test (Serum)

Published: August 9, 2026Updated: August 16, 2026

This test checks for antibodies against centromere proteins, which may be linked to certain autoimmune conditions affecting the kidneys or lungs.

Quick summary

["Helps identify rare autoimmune disorders that can cause kidney or lung problems."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
56734-7
Short code
CENPB
Synonyms
Centromere B Ab Ser Ql IB
Category
chemistry
Sample
serum
Container
Serum separator tube (SST) or red top tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
Immunoblot (Western Blot)
CPT
83516
SNOMED
39517006
Specimen volume
0.5-1 mL serum
Stability
Stable for 7 days at 2-8°C; for longer storage, freeze at -20°C or below
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
24–72 hours
Order
routine

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like kidney issues (e.g., swelling, blood in urine), lung problems (e.g., shortness of breath), or if you have a history of autoimmune diseases. It’s also sometimes used in patients with unexplained skin rashes or joint pain.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from your arm. The test is done on serum (liquid part of blood after clotting).

What the Test Measures

The test detects the presence of antibodies targeting centromere proteins, which are essential for normal cell division. Elevated levels may suggest an autoimmune response.

Possible Results and Next Steps

A positive result means antibodies are present, which may indicate a condition like systemic sclerosis (scleroderma) or other centromere antibody-related disorders. Follow-up may include further testing or monitoring by a specialist.

Reference range

NegativeN/A

Specimen: serum

No special preparation required. Fasting is not required prior to specimen collection.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Centromere Antibody Screen

Frequently asked questions

What does a positive result mean?
A positive result suggests you may have an autoimmune condition affecting the kidneys, lungs, or skin. This doesn’t diagnose a specific disease but may guide further evaluation, such as additional blood tests or imaging.
Can this test be used to diagnose a disease?
No, this test alone isn’t diagnostic. It’s often used as part of a broader evaluation, including clinical symptoms, physical exams, and other tests to identify underlying conditions like systemic sclerosis or other autoimmune diseases.
How often should I get this test?
Your provider will determine how often you need retesting based on your symptoms, medical history, and response to treatment. Regular monitoring may be recommended if you have an existing autoimmune condition.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy