Antibody to Centromere Proteins (Centromere Antibody Test)
This test measures antibodies against centromere proteins, which are found in the centromere region of chromosomes. These antibodies are often linked to a specific autoimmune condition.
["This test helps diagnose autoimmune disorders affecting the kidneys."]
Key facts at a glance
- LOINC
- 54001-3
- Short code
- CENPF
- Synonyms
- Centromere F Ab Ser Ql IF
- Category
- chemistry
- Sample
- serum
- Container
- Serum separator tube (SST) or red-top tube
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- Immunofluorescence (IFA)
- CPT
- 86235
- SNOMED
- 164689006
- Specimen volume
- 1-2 mL of serum
- Stability
- Stable for 7 days at 2-8°C; for longer storage, freeze at -20°C or below
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 48–168 hours
- Order
- routine
What Is This Test For?
Centromere antibodies are detected through a blood sample. This test is primarily used to identify systemic sclerosis (scleroderma) or limited cutaneous systemic sclerosis, where antibodies may target centromere proteins. It can also be part of evaluating other autoimmune-related kidney conditions.
Why Might You Need This Test?
Your healthcare provider may recommend this test if you have symptoms like skin thickening, joint pain, or kidney issues, and you may have other autoimmune-related conditions. It helps confirm a diagnosis or monitor disease activity.
How Is the Test Performed?
A blood sample is drawn from a vein in your arm. The sample is then tested in a lab to detect the presence of centromere antibodies using immunoassay methods.
What Are Possible Results?
A positive result indicates the presence of centromere antibodies, which may suggest a diagnosis of systemic sclerosis or related autoimmune conditions. A negative result means no detectable antibodies were found in this test.
Reference range
NegativeN/A
No special patient preparation required. Specimen collection may be performed at any time of day.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: Centromere antibodies are strongly associated with limited cutaneous systemic sclerosis, a form of scleroderma. They can help differentiate between subtypes of scleroderma and guide treatment decisions. Elevated levels may also indicate kidney involvement, which requires careful monitoring.
Short name
Centromere Antibody (Screen)
Frequently asked questions
What does a positive result mean?
How often should I get this test?
Can lifestyle changes affect this test result?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy