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Cyclic Citrullinated Peptide 1 Antibody, Serum — Immunoassay, Arbitrary Concentration

Published: August 9, 2026Updated: August 16, 2026

A blood test that detects antibodies to cyclic citrullinated peptide 1. It can help support a diagnosis of rheumatoid arthritis when symptoms and other findings are present.

Quick summary

["A positive anti-CCP1 result may support rheumatoid arthritis, but it must be interpreted with your symptoms and other tests."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
96561-6
Short code
CEP-1 Ab Ser IA-aCnc
Synonyms
CEP-1 Ab Ser IA-aCnc
Category
liver
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This blood test looks for antibodies directed against cyclic citrullinated peptide 1, a protein that can be modified in joints affected by rheumatoid arthritis. It is often called the anti-CCP1 test.

Why might I need this test?

The test may be ordered for people with joint pain, swelling, stiffness, or other symptoms that suggest rheumatoid arthritis. It is especially useful when the diagnosis is uncertain based on symptoms and examination alone.

How is the test performed?

A blood sample is drawn and tested in a laboratory using an immunoassay, which detects anti-CCP1 antibodies. The result is reported as an antibody concentration using the laboratory's testing method.

How do I prepare for the test?

Fasting is usually not required for this test. Follow any specific instructions from your healthcare professional or laboratory, and tell the laboratory if you are pregnant or have recently received biologic treatment.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Cyclic citrullinated peptide 1 antibody (anti-CCP1)

Frequently asked questions

Does a positive anti-CCP1 result mean I have rheumatoid arthritis?
Not necessarily. A positive result increases the likelihood of rheumatoid arthritis, especially with compatible symptoms, but it must be interpreted by a clinician alongside other examinations and tests.
Can people with rheumatoid arthritis have a negative anti-CCP1 result?
Yes. Some people with rheumatoid arthritis do not have detectable anti-CCP1 antibodies, so a negative result does not completely rule out the condition.
Is this the same as a rheumatoid factor test?
No. Anti-CCP1 and rheumatoid factor are different antibody tests that can be used together to help evaluate the possibility of rheumatoid arthritis.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy