Serum Ceruloplasmin (Mass Concentration)
This test measures the amount of ceruloplasmin, a protein in your blood that helps remove excess copper and plays a role in iron metabolism.
["Ceruloplasmin helps detect copper storage disorders or iron-related conditions."]
Key facts at a glance
- LOINC
- 29213-6
- Short code
- CERPLAS
- Synonyms
- Ceruloplasmin Fld-mCnc
- Category
- chemistry
- Sample
- serum
- Container
- Serum separator tube (SST) or red-top tube without anticoagulant
- Units
- N/A
- Ref low
- 20
- Ref high
- 60
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- ≥ 0 years
- Method
- Nephelometry or Immunoturbidimetry
- CPT
- 82390
- SNOMED
- 105327008
- Specimen volume
- 1-2 mL of serum
- Stability
- Stable for 8 hours at room temperature (15-25°C); 2 weeks at 2-8°C; up to 6 months frozen at -20°C or below. Avoid repeated freeze-thaw cycles.
- Hemolysis max
- 100
- Lipemia max
- 200
- Icterus max
- 50
- TAT
- 4–24 hours
- Order
- routine
Why Is This Test Done?
Your healthcare provider may order this test if you have symptoms of copper toxicity, liver disease, or conditions like Wilson’s disease, where copper buildup occurs. It may also be checked in people with unexplained iron overload or certain genetic disorders affecting copper metabolism.
What Does the Result Mean?
Results are not typically provided as a single reference range since ceruloplasmin levels can vary based on health status and method. High levels may suggest liver disease or iron deficiency, while low levels could indicate copper storage disorders or Wilson’s disease.
Sample Preparation
This test uses a blood sample drawn from a vein, usually in a clinic or lab. You may be asked to fast for a few hours before the test, but this is not always required.
Common Conditions Monitored
Ceruloplasmin is often checked alongside other blood tests to diagnose or monitor conditions like Wilson’s disease, hemochromatosis (iron overload), or copper metabolism disorders.
Reference range
Ceruloplasmin reference range for adults: 20-60 mg/dL (0.2-0.6 g/L) in serum. Values may vary slightly based on analytical method and laboratory. Pediatric reference ranges differ and should be consulted separately.N/A
No fasting required. Patients should inform their healthcare provider of any recent infections, inflammation, pregnancy, or medications including oral contraceptives and estrogen therapy, as these may elevate ceruloplasmin levels.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
Ceruloplasmin
Frequently asked questions
What might cause my ceruloplasmin levels to be abnormal?
How long does it take to get my results?
Can I eat or drink before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy