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Serum Creatinine Concentration (Quantitative)

Published: August 9, 2026Updated: August 15, 2026

This test measures the amount of creatinine, a waste product from muscle metabolism, in your blood serum. It helps assess how well your kidneys are filtering blood.

Quick summary

["Kidney function check via creatinine levels."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 15, 2026Editorial policy

Key facts at a glance

LOINC
49195-1
Short code
CALIFVIGG
Synonyms
CEV IgG Ser-aCnc
Category
chemistry
Sample
serum
Container
Serum separator tube (SST) or red-top tube
Units
N/A
Ref low
0
Ref high
1
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
Enzyme Immunoassay (EIA)
CPT
86651
SNOMED
122300009
Specimen volume
1-2 mL serum (minimum 0.5 mL)
Stability
Room temperature: 8 hours; Refrigerated (2-8°C): 7 days; Frozen (-20°C or below): 30 days; avoid repeated freeze-thaw cycles
Hemolysis max
100
Lipemia max
100
Icterus max
50
TAT
48–168 hours
Order
routine

Why Is This Test Done?

Your doctor may order this test to evaluate kidney function, monitor chronic kidney disease, detect early kidney problems, or check for conditions affecting muscle breakdown (e.g., rhabdomyolysis). It’s often used alongside other tests like blood urea nitrogen (BUN) to assess kidney health.

What Does a Result Mean?

Higher-than-normal levels may indicate reduced kidney function, dehydration, or conditions that increase muscle breakdown. Lower-than-normal levels could suggest overhydration or muscle wasting. Results are interpreted in relation to your overall health and other tests.

How Is This Test Performed?

A blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab where it’s analyzed to measure creatinine concentration using a standardized method.

What Are Common Causes of Abnormal Results?

Elevated creatinine levels may be caused by kidney disease, dehydration, severe muscle injury, or conditions like diabetes or heart failure. Low levels might result from overhydration, liver disease, or certain medications.

Reference range

Negative: <1:10 titer; Positive: ≥1:10 titerN/A

Specimen: serum

No special patient preparation required. Specimen collection may coincide with acute phase of illness (within first week of symptom onset) and convalescent phase (2-4 weeks later) for seroconversion confirmation.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Serum Creatinine

Frequently asked questions

Why might my creatinine level be higher than expected?
Possible reasons include kidney disease, dehydration, muscle breakdown (e.g., from strenuous exercise or injury), or certain medications. Your doctor will consider your overall health and other test results to determine the cause.
How often should I get this test?
Frequency depends on your health condition. If you have kidney disease, diabetes, or another risk factor, your doctor may recommend testing every few months or annually. Regular monitoring helps track changes in kidney function over time.
Does diet affect creatinine levels?
Dietary protein intake can influence creatinine levels, but the effect is usually small. High-protein diets may temporarily raise levels, while very low-protein diets might lower them. Your doctor will assess this in relation to your overall health and medical history.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy