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C-reactive protein, serum/plasma concentration (high-sensitivity)

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of a protein called C-reactive protein (CRP) in your blood. CRP is produced by your liver in response to inflammation, helping your body fight infections and injuries.

Quick summary

["CRP helps doctors assess inflammation, which can signal underlying health issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
46769-6
Short code
CF DBS-Imp
Synonyms
CF DBS-Imp
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order this test to monitor conditions like heart disease, autoimmune disorders, or infections. High CRP levels may indicate inflammation, while low levels suggest reduced inflammation. It’s also used to track how well treatments are working for certain conditions.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into a vein in your arm to draw blood. If you’re on blood thinners, let your provider know before the test.

What the Results Mean

Results are typically reported in milligrams per liter (mg/L). While reference ranges vary by lab, elevated levels (above typical reference) may signal inflammation, infections, or other health concerns. Your provider will interpret results in the context of your overall health.

Common Conditions Monitored

High-sensitivity CRP is often used to evaluate risk for cardiovascular diseases, track inflammatory conditions (like rheumatoid arthritis), or check for signs of infection. It’s also useful for assessing response to treatments for these conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

hsCRP

Frequently asked questions

What does a high CRP level mean?
A high CRP level often points to inflammation in your body, which can be caused by infections, injuries, autoimmune diseases, or other health issues. Your provider will review your symptoms and other test results to determine the cause.
Can I eat or drink before this test?
You can eat and drink normally before this test unless your provider instructs otherwise. No fasting is required for this blood test.
How often should I get this test?
The frequency depends on your health condition and treatment plan. Your provider will let you know how often to get this test based on your needs, such as monitoring heart health, autoimmune diseases, or other chronic conditions.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy