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###1: Calculated Serum Globulin and Total IgE

Published: August 9, 2026Updated: August 15, 2026

###3: This test estimates globulin from your serum protein results and measures total immunoglobulin E (IgE), an antibody involved in allergic and immune responses.

Quick summary

["###4: The results may help evaluate immune or inflammatory conditions, but they must be interpreted with symptoms, medical history, and other laboratory findings."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 15, 2026Editorial policy

Key facts at a glance

LOINC
61242-4
Short code
CHAETIGE
Synonyms
C globosum IgE/IgE total %
Category
chemistry
Sample
serum
Container
Serum separator tube (SST) or red-top vacutainer tube
Units
N/A
Ref low
0
Ref high
0.35
Fasting
false
Population
adult
Sex
all
Age range
0–99 years
Method
Fluorescence Enzyme Immunoassay (FEIA) / ImmunoCAP
CPT
86003
SNOMED
395141001
Specimen volume
1.0 mL serum (minimum 0.5 mL)
Stability
Stable at room temperature for 8 hours; refrigerated (2-8°C) for 7 days; frozen (-20°C) for 30 days. Avoid repeated freeze-thaw cycles.
Hemolysis max
100
Lipemia max
100
Icterus max
50
TAT
24–72 hours
Order
routine

###5: What the test measures

###6: Calculated globulin is usually estimated by subtracting the albumin level from the total protein level. It represents the globulin fraction, which includes antibodies and other proteins. Total IgE is measured directly as the overall amount of IgE in the blood.

###7: How the results are interpreted

###8: A high calculated globulin level can occur with inflammation, infection, liver disease, or conditions that increase antibody production. A high total IgE level may be associated with allergies, certain parasitic infections, or immune disorders. Results are considered together rather than in isolation.

###9: Why the test may be ordered

###10: Clinicians may order these measurements when evaluating recurring allergies, unexplained swelling, suspected immune or inflammatory disorders, protein abnormalities, or symptoms involving the liver, lungs, skin, or blood.

###11: Preparation and sample collection

###11: The test requires a blood sample collected by venipuncture. Tell your healthcare professional if you have a known IgE deficiency, are taking biologic medicines or immunosuppressive therapy, or have recently received certain blood products, because these can affect interpretation.

Reference range

IgE total: 0-100 kU/L (adults); Specific IgE to Chaetomium globosum: <0.35 kU/L (negative/undetectable), 0.35-0.69 kU/L (low/equivocal), 0.70-3.49 kU/L (moderate), 3.50-17.49 kU/L (high), 17.50-49.99 kU/L (very high), >50 kU/L (very high)N/A

Specimen: serum

No fasting required. Patient should discontinue antihistamines only if skin testing is planned concurrently. Inform provider of all current medications including corticosteroids and immunosuppressants.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

###13: Clinical significance: Calculated globulin and total IgE can provide useful clues about immune and inflammatory activity, but neither result diagnoses a specific condition. IgE may be elevated even when an allergy cannot be identified, and abnormal globulin may reflect several different diseases. Your clinician should interpret the results using your symptoms, examination, medication history, and other tests.

Short name

###2: Calculated globulin and total IgE

Frequently asked questions

###14: Does a high IgE level confirm that I have an allergy?
###15: No. Elevated total IgE is associated with allergies and some other immune or infectious conditions, but it does not identify the specific allergen or establish a diagnosis by itself.
###16: What does a high calculated globulin level mean?
###17: It may reflect inflammation, infection, liver disease, or increased antibody production. Your healthcare professional will consider these possibilities along with the albumin, total protein, symptoms, and other laboratory results.
###18: Can medicines or medical treatments affect these results?
###19: Yes. Immunosuppressive medicines, biologic therapies, some immune disorders, and certain recent treatments can alter IgE or protein measurements. Tell your clinician about medications, infusions, transfusions, and relevant medical history before the test is interpreted.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy