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Guillain-Barré Syndrome Antibody Profile (IgG) – Serum Immunoassay Panel

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies in your blood that may be linked to Guillain-Barré Syndrome (GBS), a rare but serious condition causing muscle weakness and nerve damage. It helps doctors assess your immune response to certain proteins.

Quick summary

["This test can help diagnose or monitor Guillain-Barré Syndrome by detecting specific antibodies linked to nerve inflammation."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
92795-4
Short code
CGDNA
Synonyms
C guilliermondii DNA Bld Pos Ql NAA+pr
Category
chemistry
Sample
whole-blood
Container
Positive blood culture broth bottle (aerobic or anaerobic); blood culture bottles should be collected in standard FDA-cleared culture bottles (e.g., BACTEC, BacT/ALERT) and incubated until flagged positive
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
≥ 0 years
Method
probe-amp-tar
CPT
87481
SNOMED
122450008
Specimen volume
1.0-3.0 mL aliquot from positive blood culture broth (positive broth is taken from the blood culture bottle under aseptic conditions)
Stability
Positive blood culture broth should be tested as soon as possible after the instrument flags positive. If testing is delayed, refrigerate broth aliquot at 2-8°C for up to 24 hours; otherwise freeze at -70°C or lower for longer storage. Avoid repeated freeze-thaw cycles.
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
1–4 hours
Order
routine

What Does This Test Measure?

The test detects IgG antibodies against common antigens (such as *Ganglioside GM1*, *GQ1b*, or *NeuGM2*) that are often implicated in Guillain-Barré Syndrome. These antibodies may attack nerve cells, leading to muscle weakness and paralysis. Results are qualitative (positive/negative) rather than quantitative.

Why Might You Need This Test?

Your doctor may order this test if you have symptoms like sudden weakness, numbness, or tingling—especially after a recent infection. It’s also used to confirm or rule out Guillain-Barré Syndrome in suspected cases.

How Is This Test Performed?

A blood sample is drawn from a vein, typically in your arm. The serum portion is tested using an immunoassay method to identify specific antibodies. Results are reported as positive or negative for the tested antigens.

What Are Common Symptoms to Watch For?

Symptoms of Guillain-Barré Syndrome may include progressive muscle weakness, loss of reflexes, difficulty walking, or paralysis. Seek medical attention immediately if you experience sudden weakness or numbness, especially if it spreads upward from your legs.

Reference range

Negative (Candida guilliermondii DNA not detected)N/A

Specimen: whole-blood

No special patient preparation required. Specimen is collected from an already-positive blood culture bottle, not directly from the patient. Standard aseptic blood culture collection technique (2-3 sets from separate venipuncture sites) is required prior to blood culture positivity.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: This test is critical for diagnosing Guillain-Barré Syndrome by identifying immune-mediated nerve damage. While not definitive alone, positive results suggest a high likelihood of the condition and guide further testing or treatment. False positives are rare but possible, so clinical correlation with symptoms and history is essential.

Short name

Guillain-Barré Antibody Screen

Frequently asked questions

How long does it take to get results from this test?
Results are typically available within 24 to 48 hours, depending on lab processing times. Your doctor will discuss the findings with you during your follow-up visit.
What should I do if my test results are positive for Guillain-Barré antibodies?
If your test is positive, your doctor will likely order additional tests (like nerve conduction studies) and monitor your symptoms closely. Treatment may include supportive care (like physical therapy) or medications to slow disease progression.
Can I prevent Guillain-Barré Syndrome?
There’s no guaranteed way to prevent Guillain-Barré Syndrome, but avoiding infections (like campylobacter or Zika virus) and maintaining a healthy immune system may reduce risk. If you suspect symptoms, seek medical attention promptly.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy