Serum Creatinine Phosphokinase (CPK) Isoenzyme Analysis (Total CPK)
This test measures the total level of Creatine Phosphokinase (CPK), an enzyme found in heart, muscle, and brain cells. It helps assess damage to these tissues.
["CPK levels can indicate muscle, heart, or brain injury or other conditions affecting these organs."]
Key facts at a glance
- LOINC
- 109161-0
- Short code
- CLADIGG
- Synonyms
- C herbarum IgG Msmt Ser
- Category
- chemistry
- Sample
- serum
- Container
- Serum separator tube (SST) or red-top tube without anticoagulant
- Units
- N/A
- Ref low
- 0.35
- Ref high
- 0.7
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- ≥ 1 years
- Method
- Immunoassay (e.g., ELISA or Fluorescence Enzyme Immunoassay [FEIA])
- CPT
- 86001
- SNOMED
- 395112001
- Specimen volume
- 1-2 mL of serum
- Stability
- Stable for 7 days at 2-8°C; for longer storage, freeze at -20°C or below. Avoid repeated freeze-thaw cycles.
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 24–96 hours
- Order
- routine
What CPK Does in Your Body
CPK is an enzyme that plays a role in energy production in cells. When tissues like your heart or muscles are damaged, CPK leaks into your bloodstream, raising its level. This test helps doctors identify where and how severe the damage might be.
Why Your Doctor Might Order This Test
Your doctor may order this test if you have symptoms like chest pain, muscle weakness, or unexplained fatigue. It’s also used after a heart attack, stroke, or injury to monitor recovery or diagnose conditions like muscle disorders.
Common Conditions Monitored
High CPK levels can signal muscle injuries (e.g., from overexertion or trauma), heart problems (such as a heart attack), or neurological conditions. Low levels may rarely indicate certain metabolic or genetic disorders.
What to Expect Before the Test
No special preparation is needed, but you may be asked to fast or avoid certain foods/drugs depending on your doctor’s instructions. Bring any medications you’re taking.
Reference range
Reference ranges are laboratory-specific and method-dependent. Generally, results are reported in qualitative categories (negative, equivocal, positive) or quantitative units (e.g., kU/L or mg/L). Negative: <0.35 kU/L; Equivocal: 0.35-0.70 kU/L; Positive: >0.70 kU/L (example values; consult your laboratory).N/A
No fasting required. No special patient preparation is typically needed prior to specimen collection. Patients should inform their healthcare provider of all medications and supplements being taken.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Total CPK
Frequently asked questions
How long does it take to get results?
Can CPK levels be affected by exercise?
What if my CPK is elevated?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy