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Chicken-Triggered Histamine Release Test

Published: August 9, 2026Updated: August 17, 2026

This blood test checks whether your blood cells release histamine when exposed to chicken proteins, which helps diagnose a chicken allergy.

Quick summary

{"This test diagnoses an allergy to chicken or chicken products","A small blood sample is taken and mixed with chicken extracts to measure histamine release","Results help your doctor determine if you need to avoid chicken in your diet","The test is safe and can be performed regardless of current medications","Positive results indicate an allergic reaction to chicken proteins"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
7223-1
Short code
CTHR
Synonyms
Chicken BasoBnd Ab Qn
Category
cardiac
Sample
whole-blood
Container
Lavender top (EDTA) tube - whole blood
Units
N/A
Ref low
0
Ref high
10
Critical range
— – 10000 N/A
Fasting
false
Population
adult
Sex
all
Age range
≥ 0 years
Method
Cellular allergen stimulation test (CAST) - histamine release from basophils upon challenge with chicken antigen
CPT
86003
SNOMED
424817003
Specimen volume
3-5 mL whole blood
Stability
Specimen must be processed within 4 hours of collection. Room temperature storage preferred. Do not refrigerate.
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
48–168 hours
Order
routine

What is this test?

The chicken-triggered histamine release test is a blood test that checks whether your immune system reacts allergically to chicken. When you have an allergy, certain white blood cells (called basophils) release histamine when they encounter an allergen. This test measures that histamine release to determine if you are allergic to chicken.

How is the test performed?

A healthcare professional will draw a small blood sample from your arm using a needle. The blood is then sent to a laboratory where it is mixed with chicken protein extracts. The lab measures the amount of histamine released from your blood cells. The entire procedure takes just a few minutes for the blood draw.

Do I need to prepare for the test?

No special preparation is needed for this test. You do not need to fast or stop taking medications. However, it is important to inform your doctor about any medications you are currently taking, as some drugs may affect test results.

What do the results mean?

If your test shows significant histamine release when exposed to chicken proteins, it indicates you may have a chicken allergy. Your doctor will interpret the results along with your symptoms and medical history to determine the best course of action, which may include avoiding chicken and chicken products.

Reference range

Histamine release < 10 ng/mL is considered negative; 10-25 ng/mL is borderline; > 25 ng/mL is positive for chicken allergyN/A

Specimen: whole-blood

Patient should discontinue antihistamines (H1 blockers) at least 5-7 days prior to testing. Beta-blockers and corticosteroids may affect results and should be discussed with ordering physician. No dietary restrictions required.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Frequently asked questions

Why would my doctor order this test?
Your doctor may order this test if you have symptoms that suggest a food allergy, such as reactions after eating chicken. Symptoms may include skin rashes, itching, stomach problems, breathing difficulties, or swelling. This test helps confirm whether chicken is the cause of your allergic reactions.
Is this test painful?
The test involves a simple blood draw, which may cause brief discomfort or a slight sting when the needle is inserted. The pain is minimal and typically well-tolerated. Some people may experience mild bruising at the injection site afterward.
How long does it take to get results?
Results are typically available within a few days to a week, depending on the laboratory. Your doctor will contact you with the results and discuss what they mean for your health.
Can I still eat chicken before the test?
You can eat your normal diet before the test. There is no need to avoid chicken or any other foods prior to the test, as this test measures your body's baseline allergic response.
What happens if I test positive for chicken allergy?
If you test positive, your doctor will likely recommend avoiding chicken and chicken-containing products. They may also prescribe emergency medication such as antihistamines or an epinephrine auto-injector for severe reactions. Your doctor will provide personalized guidance based on your specific results and symptoms.
  1. 1
    American College of Allergy, Asthma & Immunology (ACAAI) - Food AllergySource
  2. 2
    Mayo Clinic - Food AllergySource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy