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C-reactive protein (CRP) in serum/plasma

Published: August 9, 2026Updated: August 15, 2026

This test measures the level of C-reactive protein, a protein produced by the liver in response to inflammation in your body.

Quick summary

["CRP helps doctors assess inflammation, often used to monitor conditions like infections or autoimmune diseases."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 15, 2026Editorial policy

Key facts at a glance

LOINC
7593-7
Short code
CHIHIST
Synonyms
Chili Pepper BasoBnd Ab Qn
Category
chemistry
Sample
whole-blood
Container
Heparinized (green-top) tube for whole blood basophil histamine release testing
Units
N/A
Ref low
0
Ref high
0.1
Fasting
false
Population
adult
Sex
all
Age range
≥ 2 years
Method
Allergen-specific histamine release assay using whole blood basophil activation
CPT
86003
SNOMED
395140001
Specimen volume
5-10 mL of whole blood
Stability
Specimen should be processed within 2-4 hours of collection; keep at room temperature (18-25°C); do not refrigerate or freeze
Hemolysis max
100
Lipemia max
100
Icterus max
50
TAT
24–72 hours
Order
routine

Why Is This Test Done?

Your healthcare provider may order a CRP test to check for signs of inflammation, monitor chronic conditions like arthritis or heart disease, or evaluate symptoms such as fever, pain, or swelling that suggest an infection or other issues.

What to Expect Before the Test

No special preparation is usually needed. You may be asked to fast before the test, depending on the lab’s instructions. Bring any medications you’re taking to your appointment.

What Happens During the Test?

A healthcare professional will draw blood from a vein in your arm. You may feel a small pinch, but it usually doesn’t cause discomfort. The blood sample is then sent to the lab for analysis.

What Are the Results?

Results are typically reported in milligrams per liter (mg/L). Higher levels may indicate inflammation, infection, or other health concerns. Your doctor will interpret the results in the context of your medical history and symptoms.

Reference range

Negative: <0.1 ng/mL; results interpreted qualitatively as positive or negative for chili pepper sensitivityN/A

Specimen: whole-blood

No fasting required. Patients should discontinue antihistamines, corticosteroids, and other allergy medications for 5-7 days prior to testing as recommended by the ordering physician. Inform provider of any recent allergic reactions or immunotherapy.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CRP

Frequently asked questions

What does a high CRP level mean?
A high CRP level suggests inflammation is present in your body. This could be due to infections, autoimmune disorders, or other health issues. Your doctor will review the results with you to determine the next steps.
What does a low CRP level mean?
A low CRP level usually means there is little to no inflammation detected in your blood. However, it doesn’t rule out other conditions that might not cause inflammation. Your doctor will consider the full picture when making a diagnosis.
Can lifestyle changes affect CRP levels?
Yes, lifestyle factors like diet, exercise, and smoking can influence CRP levels. Reducing inflammation through healthy habits—such as eating a balanced diet, staying active, and avoiding smoking—may help lower CRP levels over time.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 15, 2026. · Read our editorial policy