Chloridesweatscnscnc
A sweat chloride test measures the amount of chloride in sweat to screen for cystic fibrosis.
{"The sweat chloride test is the gold standard for diagnosing cystic fibrosis","It measures the amount of salt (chloride) in sweat","Higher than normal chloride levels indicate cystic fibrosis","The test is simple, painless, and safe for all ages","Results are typically available within a few days"}
Key facts at a glance
- LOINC
- 56448-4
- Short code
- CLSWEAT
- Synonyms
- Chloride Sweat Scn-sCnc
- Category
- electrolyte
- Sample
- serum
- Container
- Sweat collection apparatus with pilocarpine iontophoresis system
- Units
- not specified
- Ref low
- 0
- Ref high
- 29
- Critical range
- — – 60 not specified
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 0–120 years
- Method
- screen
- CPT
- 89230
- SNOMED
- 41316001
- Specimen volume
- Minimum 75 mg sweat weight (approximately 75-100 μL)
- Stability
- Analyze within 24 hours; if delay, store at 2-8°C up to 72 hours
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 24–72 hours
- Order
- routine
What is this test?
The sweat chloride test, also known as the sweat test, measures the concentration of chloride (a component of salt) in your sweat. It is primarily used to diagnose cystic fibrosis (CF), a genetic disorder that affects the lungs, digestive system, and other organs. People with cystic fibrosis have higher than normal levels of chloride in their sweat because the chloride channels do not work properly.
How is the test performed?
During the test, a small area of the skin (usually on the arm or leg) is stimulated to produce sweat using a mild electrical current or a sweat-inducing chemical. The sweat is collected on a filter paper or in a coil, and then sent to a laboratory for analysis. The entire procedure is painless and typically takes about 30 minutes to an hour. The test is safe for infants, children, and adults.
What do the results mean?
Normal sweat chloride levels are less than 30 mmol/L. Levels between 30-59 mmol/L are considered borderline, and levels of 60 mmol/L or higher are indicative of cystic fibrosis. However, your healthcare provider will interpret your results in the context of your symptoms and other test results. Sometimes the test may need to be repeated to confirm the diagnosis.
Why is this test important?
Early diagnosis of cystic fibrosis is crucial for starting treatment as soon as possible. The sweat test is the gold standard for CF diagnosis because it is highly accurate and reliable. Detecting CF early allows patients to receive timely treatment, which can significantly improve quality of life and long-term outcomes.
Reference range
≤29 mmol/Lnot specified
No fasting required; ensure adequate hydration; avoid applying lotions, creams, powders or deodorants to collection sites; withhold mineralocorticoids if possible
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings2
Frequently asked questions
Is the sweat test painful?
How long does it take to get results?
Do I need to prepare for the test?
Can the test be done on newborns?
What happens if my results are borderline?
Sources
- 1
- 2
- 3MedlinePlus - Sweat TestSource
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy