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Chloridesweatscnscnc

Published: July 31, 2026Updated: August 16, 2026

A sweat chloride test measures the amount of chloride in sweat to screen for cystic fibrosis.

Quick summary

{"The sweat chloride test is the gold standard for diagnosing cystic fibrosis","It measures the amount of salt (chloride) in sweat","Higher than normal chloride levels indicate cystic fibrosis","The test is simple, painless, and safe for all ages","Results are typically available within a few days"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
56448-4
Short code
CLSWEAT
Synonyms
Chloride Sweat Scn-sCnc
Category
electrolyte
Sample
serum
Container
Sweat collection apparatus with pilocarpine iontophoresis system
Units
not specified
Ref low
0
Ref high
29
Critical range
— – 60 not specified
Fasting
false
Population
adult
Sex
all
Age range
0–120 years
Method
screen
CPT
89230
SNOMED
41316001
Specimen volume
Minimum 75 mg sweat weight (approximately 75-100 μL)
Stability
Analyze within 24 hours; if delay, store at 2-8°C up to 72 hours
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
24–72 hours
Order
routine

What is this test?

The sweat chloride test, also known as the sweat test, measures the concentration of chloride (a component of salt) in your sweat. It is primarily used to diagnose cystic fibrosis (CF), a genetic disorder that affects the lungs, digestive system, and other organs. People with cystic fibrosis have higher than normal levels of chloride in their sweat because the chloride channels do not work properly.

How is the test performed?

During the test, a small area of the skin (usually on the arm or leg) is stimulated to produce sweat using a mild electrical current or a sweat-inducing chemical. The sweat is collected on a filter paper or in a coil, and then sent to a laboratory for analysis. The entire procedure is painless and typically takes about 30 minutes to an hour. The test is safe for infants, children, and adults.

What do the results mean?

Normal sweat chloride levels are less than 30 mmol/L. Levels between 30-59 mmol/L are considered borderline, and levels of 60 mmol/L or higher are indicative of cystic fibrosis. However, your healthcare provider will interpret your results in the context of your symptoms and other test results. Sometimes the test may need to be repeated to confirm the diagnosis.

Why is this test important?

Early diagnosis of cystic fibrosis is crucial for starting treatment as soon as possible. The sweat test is the gold standard for CF diagnosis because it is highly accurate and reliable. Detecting CF early allows patients to receive timely treatment, which can significantly improve quality of life and long-term outcomes.

Reference range

≤29 mmol/Lnot specified

Specimen: serum

No fasting required; ensure adequate hydration; avoid applying lotions, creams, powders or deodorants to collection sites; withhold mineralocorticoids if possible

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings2

Frequently asked questions

Is the sweat test painful?
No, the sweat test is not painful. You may feel a tingling or warming sensation during the stimulation process, but it is generally well-tolerated by patients of all ages, including newborns.
How long does it take to get results?
Results are typically available within 1-3 days after the sample is collected. Your healthcare provider will discuss the results with you during a follow-up appointment.
Do I need to prepare for the test?
No special preparation is needed. You should continue your normal activities and medications unless your healthcare provider instructs otherwise. However, you should avoid applying creams, lotions, or oils to the test area on the day of the test.
Can the test be done on newborns?
Yes, the sweat test can be performed on newborns. In fact, newborn screening for cystic fibrosis often includes the sweat test if the initial blood test suggests possible CF. The test is safe and can be done within the first few days of life if needed.
What happens if my results are borderline?
If your sweat chloride levels are in the borderline range (30-59 mmol/L), your doctor may recommend repeating the test. They may also order additional tests, such as genetic testing or nasal potential difference measurement, to help confirm or rule out cystic fibrosis.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy