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Complete Blood Count (CBC): What You Need to Know

Published: July 31, 2026Updated: August 16, 2026

A laboratory test that measures chloride levels in the vitreous fluid of the eye.

Quick summary

{"Measures chloride concentration in the vitreous humor of the eye","Helps evaluate electrolyte balance and eye health","Used primarily in ophthalmology and forensic medicine","Abnormal levels may indicate underlying systemic or ocular conditions","Sample is collected from the vitreous cavity of the eye"}

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
12898-3
Short code
Cl-Vitreous
Synonyms
Chloride Vitf-sCnc
Category
electrolyte
Sample
serum
Container
Sterile glass or plastic container, typically collected via vitreous tap (vitreocentesis) using a 19-22 gauge needle
Units
not specified
Ref low
105
Ref high
135
Fasting
false
Population
adult
Sex
all
Age range
0–120 years
Method
Ion-selective electrode (ISE) potentiometry or indirect potentiometry
CPT
82436 ( Chloride, body fluid ) or 84305 ( Electrolyte panel, body fluid )
SNOMED
39654006 ( Chloride measurement ) or 27922009 ( Vitreous fluid )
Specimen volume
0.5-2.0 mL preferably, minimum 0.2 mL for analysis
Stability
Stable for 24-48 hours at 2-8°C; avoid freezing as this may cause cell lysis; analyze as soon as possible
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
24–72 hours
Order
routine

This test measures the different types of cells in your blood, including red blood cells, white blood cells, and platelets. It helps evaluate your overall health and detect a variety of disorders, such as anemia, infection, and certain blood cancers.

The Vitreous Fluid Chloride test measures the concentration of chloride, an important electrolyte, in the vitreous humor—the clear, gel-like substance that fills the space between the lens and the retina of the eye. Chloride is a negatively charged ion that helps maintain the body's fluid balance, acid-base balance, and is essential for proper nerve and muscle function.

A healthcare professional will draw a small sample of blood from a vein in your arm using a needle. The blood is collected into a tube and sent to a laboratory for analysis. You may feel a quick sting, but the process is generally safe and takes only a few minutes.

A small sample of vitreous fluid is collected from the eye using a thin needle in a procedure called vitreous aspiration or vitrectomy. This procedure is typically performed by an ophthalmologist in a clinical setting. The collected sample is then sent to a laboratory where the chloride concentration is measured using specialized equipment.

The CBC is important because it provides critical information about your blood health. Abnormal results can help diagnose conditions like anemia, infections, bleeding disorders, or even more serious issues such as leukemia. Regular testing can also help monitor the effects of treatments or medications on your blood cells.

Chloride plays a crucial role in maintaining the electrical neutrality and osmotic balance of the eye's internal environment. Abnormal chloride levels in the vitreous fluid can indicate various conditions affecting the eye or systemic electrolyte imbalances. This test provides valuable diagnostic information that cannot be obtained from blood tests alone.

Reference range

105-135 mmol/Lnot specified

Specimen: serum

Postmortem specimen; no living patient preparation required

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

The vitreous fluid chloride test is primarily used in ophthalmology to assess intraocular electrolyte status. Elevated or decreased chloride levels may indicate conditions such as uveitis (inflammation of the eye), retinal detachment, or other ocular diseases. In forensic medicine, analysis of vitreous humor electrolytes can help determine the cause and time of death, as postmortem changes in the eye occur more slowly than in other body fluids.

Abnormal chloride levels may also reflect systemic electrolyte disturbances, dehydration, kidney disorders, or certain metabolic conditions. The test helps ophthalmologists and other healthcare providers make accurate diagnoses and develop appropriate treatment plans for eye-related conditions.

Frequently asked questions

Is the vitreous fluid chloride test painful?
The procedure is performed under local anesthesia, so you should not feel pain during the sample collection. You may experience some mild discomfort or a sensation of pressure in the eye afterward, which typically resolves within a short time.
How long does it take to get results?
Results are usually available within a few days to a week, depending on the laboratory's processing time. Your ophthalmologist will discuss the results with you during a follow-up appointment.
Are there any risks associated with this test?
As with any procedure involving the eye, there are some risks, including minor bleeding, infection, or temporary changes in vision. However, serious complications are rare when the procedure is performed by an experienced ophthalmologist.
Do I need to fast before the test?
Your doctor will provide specific instructions. Unlike blood tests, fasting is generally not required for vitreous fluid collection, but you should follow all pre-procedure instructions provided by your healthcare provider.
How should I prepare for the test?
Inform your doctor about any eye medications you are using and any history of eye surgery or conditions. You may need to temporarily stop wearing contact lenses before the procedure. Your doctor will provide detailed preparation instructions.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy