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Multiplex bile acid profile (serum/plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures multiple bile acids in your blood, which play a key role in digestion and metabolism. It helps assess liver function, bile flow, and potential bile acid malabsorption.

Quick summary

["This test helps diagnose and monitor conditions affecting bile production or flow."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
105345-3
Short code
Cholestasis multi anl Bld/T
Synonyms
Cholestasis multi anl Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like abdominal pain, diarrhea, fatigue, or unexplained weight loss. It’s also used to evaluate conditions like liver disease, gallbladder issues, or bile acid malabsorption, especially in patients with unexplained gastrointestinal symptoms or metabolic disorders.

What to Expect Before the Test

No special preparation is typically needed, but you may be asked to fast for a few hours before the blood draw. Follow your provider’s instructions carefully to ensure accurate results.

How the Test Works

A small blood sample is taken from a vein in your arm. The sample is then analyzed to measure multiple bile acids, which are chemical compounds produced by the liver and stored in the gallbladder.

Possible Results and Interpretation

Results may show elevated or low levels of bile acids, depending on whether bile flow is blocked, impaired, or excessive. Your provider will interpret the results in the context of your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Bile acid panel

Frequently asked questions

What does a high or low bile acid level mean?
High levels may indicate conditions like liver disease, gallbladder dysfunction, or bile duct obstruction, which can affect digestion and nutrient absorption. Low levels could suggest bile acid malabsorption, often linked to gastrointestinal disorders or certain medications.
How often should I get this test?
Your provider will determine the frequency based on your symptoms, medical history, and treatment plan. Some patients may need this test periodically to monitor progression or response to treatment.
Can diet or medications affect bile acid levels?
Yes, certain foods, medications (like bile acid sequestrants), or liver conditions can influence bile acid levels. Always inform your provider about all medications and dietary habits before testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy