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Cholesterol, Cerebrospinal Fluid — Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

Measures the amount of cholesterol in cerebrospinal fluid, the fluid surrounding the brain and spinal cord. Results are interpreted alongside other cerebrospinal fluid tests.

Quick summary

["This test measures cholesterol in the fluid around the brain and spinal cord and is interpreted with other CSF test results."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
14439-4
Short code
Cholest CSF-mCnc
Synonyms
Cholest CSF-mCnc
Category
lipid
Sample
csf
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
1-2 mL
Stability
Immediate analysis required, Refrigerated: 1h
Hemolysis max
200
TAT
4–24 hours
Order
routine

What is this test?

Cerebrospinal fluid cholesterol test measures the concentration of cholesterol in the fluid surrounding the brain and spinal cord. It is not the same as a routine blood cholesterol test.

Why might I need this test?

A clinician may order this test as part of an evaluation of an unexplained neurologic condition or when examining cerebrospinal fluid for signs of infection, inflammation, or other disease. It is usually interpreted with other CSF measurements and clinical findings.

How is the test performed?

Cerebrospinal fluid is usually collected through a lumbar puncture, or spinal tap. The fluid is analyzed in a laboratory to determine its cholesterol concentration.

How do I prepare for the test?

Fasting is generally not required, but follow the instructions provided by your healthcare professional. Tell the clinician about medicines, allergies, bleeding problems, or a history of spinal or back conditions before a lumbar puncture.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CSF Cholesterol

Frequently asked questions

Is this the same as a blood cholesterol test?
No. This test measures cholesterol in cerebrospinal fluid, while a routine cholesterol test measures it in blood.
How is cerebrospinal fluid collected?
It is usually collected with a lumbar puncture, commonly called a spinal tap. A clinician inserts a needle into the space around the spinal cord and removes a small amount of fluid.
Does an abnormal result diagnose a specific condition?
No. CSF cholesterol changes can occur with several conditions, so the result must be considered together with the rest of the medical evaluation.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy