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Cholesterol, Plasma — Substance Concentration

Published: August 9, 2026Updated: August 16, 2026

Measures the amount of cholesterol in plasma, the liquid part of blood. It is commonly used to assess cardiovascular risk.

Quick summary

["This blood test measures plasma cholesterol to help evaluate heart and blood vessel disease risk."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
39468-4
Short code
Cholest Plr-sCnc
Synonyms
Cholest Plr-sCnc
Category
lipid
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

What is this test?

This test measures total cholesterol in plasma, the liquid portion of blood. Cholesterol is a fatty substance made by the body and obtained from food; it is essential for normal cell function but can build up in blood vessels.

Why might I need this test?

A cholesterol test may be used to screen for or monitor high cholesterol, which can increase the risk of heart attack and stroke. Results may also help guide diet, physical activity, and medication decisions.

How is the test performed?

A blood sample is drawn from a vein and sent to a laboratory for analysis. The laboratory measures cholesterol in the plasma, usually using an enzymatic method.

How do I prepare for the test?

Follow your clinician's instructions. Fasting may be requested for more accurate results, often by avoiding food and drinks other than water for about 9 to 12 hours beforehand, but not all cholesterol tests require fasting.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

A high cholesterol result may indicate increased cardiovascular risk, although risk also depends on other factors such as blood pressure, diabetes, smoking, and family history. A low result can occur for many reasons and should be interpreted alongside your overall health and other laboratory findings.

Short name

Plasma Cholesterol

Frequently asked questions

Does this test measure all types of cholesterol?
This test generally measures total cholesterol, which includes LDL, HDL, and other cholesterol carried in blood. Your clinician may order a lipid panel for more detailed information.
Do I need to fast before this test?
It depends on your clinician's instructions and the laboratory's testing method. If fasting is required, it is commonly recommended to avoid food and drinks other than water for about 9 to 12 hours beforehand.
Can I take medicines before this test?
Continue prescribed medicines unless your clinician tells you otherwise. Some medicines can affect cholesterol levels, so tell the laboratory if you take cholesterol-lowering or other relevant medications.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy