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Cholesterol, Total, Serum/Plasma

Published: August 9, 2026Updated: August 16, 2026

This blood test measures total cholesterol, a type of fat in the blood, and helps assess cardiovascular risk.

Quick summary

["Total cholesterol is one part of a broader assessment of heart and blood vessel risk."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
9342-7
Short code
Cholest Prctl SerPl
Synonyms
Cholest Prctl SerPl
Category
lipid
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

A total cholesterol test measures the overall amount of cholesterol in your blood. The result may include different types of cholesterol and is often reviewed with HDL, LDL, and triglyceride results.

Why might I need this test?

Clinicians may order this test during routine screening or to monitor cholesterol treatment. It can help assess your risk of heart disease and stroke, especially when other risk factors are present.

How is the test performed?

A blood sample is collected and analyzed in a laboratory for its total cholesterol content. The sample is typically taken from a vein and analyzed as serum or plasma.

How do I prepare for the test?

Fasting is often not required, but you may be asked to fast for several hours if the test is being used to evaluate lipid levels. Follow your clinician's instructions and tell the laboratory if you have recently eaten.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Total Cholesterol

Frequently asked questions

Does a total cholesterol test measure good and bad cholesterol?
It measures the total amount of cholesterol in the blood. HDL and LDL cholesterol are usually measured separately to provide more detail.
Do I need to fast before this test?
Fasting is often optional for routine total cholesterol testing, though your clinician may request it. Confirm the instructions before your blood draw.
Can medications or supplements affect the result?
Yes. Statins and some other medicines can lower cholesterol, while certain supplements or health conditions can affect the result. Tell your clinician about medications and supplements you use.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy