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Cholesterol in Small Dense LDL, Serum/Plasma — Mass Concentration

Published: August 9, 2026Updated: August 16, 2026

Measures cholesterol carried by small dense LDL particles in blood, which may help assess cardiovascular risk.

Quick summary

["Higher small dense LDL cholesterol can indicate increased risk of cholesterol-related plaque buildup in the arteries."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
90364-1
Short code
Chol.in LDL.small dense SerPl-mCnc
Synonyms
Chol.in LDL.small dense SerPl-mCnc
Category
lipid
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
0
Ref high
100
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
83721
SNOMED
113079007
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

This blood test measures the concentration of cholesterol associated with small dense LDL particles. These are a type of cholesterol-carrying lipoprotein that can contribute to plaque buildup in arteries.

Why might I need this test?

Your clinician may order this test as part of a cardiovascular risk assessment, particularly if you have high cholesterol, diabetes, metabolic syndrome, or a family history of early heart disease.

How is the test performed?

A blood sample is collected, and the laboratory measures cholesterol in the small dense LDL fraction using a validated laboratory method. It is generally reported as a mass concentration in serum or plasma.

How do I prepare for the test?

No special preparation is universally required, but fasting may be requested for some lipid testing. Follow your clinician's instructions and tell the laboratory if you have recently changed medicines, diet, or exercise habits.

Reference range

Optimal: <100 mg/dLN/A

Specimen: serum

Fasting for 12-14 hours preferred. Water is permitted. Avoid alcohol for 24 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

An elevated result may indicate an increased amount of atherogenic small dense LDL cholesterol and can be associated with higher cardiovascular risk. It should be interpreted with the rest of your lipid panel, blood pressure, diabetes status, family history, and other risk factors; the result alone does not diagnose heart disease.

Short name

Small Dense LDL Cholesterol

Frequently asked questions

What is small dense LDL?
Small dense LDL is a subtype of LDL, the lipoprotein that carries cholesterol in the blood. Its particles are smaller and denser than those of the main LDL fraction.
Does a high result mean I have heart disease?
No. A high result can indicate increased cardiovascular risk, but it does not prove that heart disease or an arterial blockage is present.
Can this test be interpreted on its own?
It is best interpreted alongside total cholesterol, HDL and LDL cholesterol, triglycerides, and your personal cardiovascular risk factors. Your clinician can explain what the result means for you.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy