Chromosomal Microarray Analysis for Deletion/Duplication at Chromosome 15q11.1–13 (Array CGH or MLPA)
This test detects small changes in DNA sequence on chromosome 15, which may be linked to genetic conditions affecting development, behavior, or physical traits.
["This test helps identify rare genetic variations that could influence health or developmental concerns."]
Key facts at a glance
- LOINC
- 82238-7
- Short code
- Chr 15q11-13 Del+Dup Amn/CVS FISH
- Synonyms
- Chr 15q11-13 Del+Dup Amn/CVS FISH
- Category
- chemistry
- Sample
- fluid
- Container
- Sterile tube
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- fish
- Specimen volume
- 2-5 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h
- Hemolysis max
- 300
- TAT
- 4–24 hours
- Order
- routine
What Does This Test Measure?
The test looks for missing or extra genetic material (deletions or duplications) in a specific region of chromosome 15, spanning genes like *UBE3A*, *NR1S1*, and others. These regions are commonly associated with conditions such as Prader-Willi syndrome or Angelman syndrome, though the exact impact depends on which genes are affected.
Why Might You Need This Test?
Your healthcare provider may recommend this test if you have symptoms like developmental delays, intellectual disability, behavioral challenges, or physical features linked to genetic disorders. It may also be used in prenatal testing if there are concerns about chromosomal abnormalities.
How Is the Test Performed?
A small blood sample is taken from you (or your child) to analyze DNA. The lab compares your genetic material to a standard reference to detect any structural changes in the chromosome region.
What Are Possible Results?
Results can include: no genetic changes detected, a confirmed deletion, a confirmed duplication, or a variant of uncertain significance (VUS) that requires further evaluation. Some findings may need additional testing or genetic counseling.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
◆Associated findings1
Short name
Chromosome 15 Microarray Test
Frequently asked questions
What Are Common Questions About This Test?
Will this test show all genetic disorders? No. It specifically targets a small region of chromosome 15 and may miss other genetic changes elsewhere in your DNA.
Can this test be done during pregnancy? Yes, prenatal testing (such as chromosomal microarray) can be performed on amniotic fluid or fetal cells to check for genetic changes before birth.
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy