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Chromosomal Microarray Analysis (CMA)

Published: August 9, 2026Updated: August 16, 2026

This test examines your DNA for structural changes or missing/fewer copies of chromosomes, which may affect how your body functions. It’s often used when other tests suggest a genetic cause for symptoms like developmental delays, intellectual disability, or physical abnormalities.

Quick summary

["A CMA helps identify potential genetic risks that might not be obvious from other tests."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
107159-6
Short code
Chrom analy Bld Microarray
Synonyms
Chrom analy Bld Microarray
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
microarray
CPT
86038
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Is a Chromosomal Microarray Analysis?

A chromosomal microarray analysis looks at your entire genome for tiny genetic changes—like extra or missing DNA pieces—that can’t always be seen with standard blood tests. These changes can influence how genes work and may contribute to health issues like learning difficulties, heart problems, or other conditions. The test uses a small sample of your blood or saliva to analyze your DNA.

How Is This Test Different from Other Genetic Tests?

Unlike traditional karyotyping (which checks for major chromosome breaks), a chromosomal microarray is more sensitive and can detect smaller genetic changes. It’s often the first test recommended when symptoms suggest a genetic link, as it covers a wide range of potential issues in a single test.

Who Might Need This Test?

Doctors may suggest a chromosomal microarray if you or your child have signs of developmental delays, intellectual disability, autism, congenital heart defects, or other unexplained health concerns. It’s also used in prenatal testing for certain high-risk pregnancies.

What Happens During the Test?

You’ll provide a small blood or saliva sample. The lab extracts DNA and compares it to a reference genome to look for any deviations. Results are usually ready within 1–2 weeks, though some may take longer depending on complexity.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Genetic Test for Chromosomal Abnormalities

Frequently asked questions

Why was I asked to take this test?
Your doctor may have recommended this test because your symptoms or medical history suggest a genetic cause. For example, it could help explain why you or your child have developmental delays, unusual facial features, or other conditions that don’t have a clear medical explanation. Knowing the cause can guide treatment, support, and future planning.
What does a positive result mean?
A positive result means the test found genetic changes that may contribute to your health concerns. These changes can vary widely—some may be associated with well-known conditions, while others might be new discoveries. Your doctor will discuss the findings with you and explain next steps, which could include further testing or monitoring.
Could this test show something I already know about?
Yes, if you or your child have a known genetic condition, the test may confirm or refine that diagnosis. It can also help identify additional genetic factors that might influence symptoms or health risks. Always discuss results with your healthcare provider.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy