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Chromatin Analysis by Flow Cytometry (Lymphocyte Subpopulation)

Published: August 9, 2026Updated: August 16, 2026

This test measures the distribution of specific nuclear components in white blood cells, often used to assess immune cell health or detect abnormalities in cell structure.

Quick summary

["Helps doctors evaluate immune function or identify genetic or cellular disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
62367-8
Short code
Chrom analy pnl FISH
Synonyms
Chrom analy pnl FISH
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
fish
CPT
86038
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test analyzes chromatin patterns in lymphocytes (a type of white blood cell) using flow cytometry. Chromatin refers to the DNA and protein complex inside cells that affects how genes are expressed. This method detects variations in chromatin structure that may indicate underlying health conditions.

Why It’s Done

Doctors may order this test if you have symptoms like unexplained fatigue, recurrent infections, or signs of immune system dysfunction. It can also help diagnose conditions like certain leukemias, genetic disorders, or immune deficiencies where chromatin abnormalities are suspected.

Sample Collection

A small blood sample is drawn from a vein, typically in your arm. The sample is processed to isolate lymphocytes, which are then analyzed for chromatin characteristics under a flow cytometer.

Preparation & Timeline

No special preparation is needed, but fasting is not required. Results may take several days to weeks, depending on lab workload and follow-up needs.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Lymphocyte Chromatin Flow

Frequently asked questions

Chromatin analysis can reveal subtle genetic or cellular changes that may not be visible through standard blood tests. For example, it may help identify inherited disorders affecting chromatin structure or detect early signs of blood cancers where chromatin abnormalities are common.
This test is not typically used for routine screening but is reserved for specific clinical scenarios where detailed lymphocyte analysis is critical.
What does a 'chromatin analysis' mean in my blood test results?
It refers to examining the DNA and protein packaging inside your white blood cells (lymphocytes). Abnormal chromatin patterns may signal genetic, immune, or blood-related conditions that require further investigation.
How long does it take to get results from this test?
Results can take anywhere from a few days to over a week, depending on lab processes and whether additional testing is needed. Your healthcare provider will discuss timelines with you.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy