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Chromatographic Analysis of Protein Electrophoresis (Serum/Plasma)

Published: August 9, 2026Updated: August 16, 2026

This test measures protein breakdown in your blood using high-performance liquid chromatography (HPLC) after separating proteins by electrophoresis. It helps assess conditions affecting protein distribution.

Quick summary

["This test helps diagnose and monitor protein disorders by identifying abnormal protein patterns in your blood."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
62352-0
Short code
Chrom analy pnl POC G-banded
Synonyms
Chrom analy pnl POC G-banded
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
g-banded
CPT
86038
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test if you have symptoms like fatigue, swelling, or unexplained weight changes. It’s also used to check for conditions like multiple myeloma, amyloidosis, or other protein-related disorders.

How the Test Works

A blood sample is drawn and separated into proteins using electrophoresis. The proteins are then analyzed by HPLC to measure their concentration and distribution across different molecular weight categories.

Sample Collection

You’ll have a small needle inserted into a vein (usually in your arm) to collect blood. The sample is sent to a lab for processing and testing.

Preparation

No special preparation is needed, but avoid heavy meals or strenuous activity 24 hours before the test.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test provides detailed information about protein patterns in your blood, which can reveal underlying disorders affecting protein synthesis, breakdown, or transport. Abnormal results may indicate conditions like monoclonal gammopathy, systemic amyloidosis, or other metabolic protein disorders.

Short name

Protein Electrophoresis Chromatography

Frequently asked questions

What Does This Test Measure?
It measures the concentration and distribution of proteins separated by size and charge, often highlighting abnormal spikes or bands that may signal protein disorders.
How Long Does It Take to Get Results?
Results are typically available within 1–3 business days, depending on lab processing times.
Can I Eat or Drink Before the Test?
Yes, you can eat and drink normally, but avoid heavy meals or alcohol 24 hours before the test.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy