Chromosomal analysis using prenatal prenatal plasma/serum-based next-generation sequencing (NGS) with fluorescent in situ hybridization (FISH) for specific gene regions
This test evaluates genetic material from your blood sample to check for potential chromosomal or gene-related risks during pregnancy.
["Helps identify possible genetic conditions that may affect your baby’s health before birth."]
Key facts at a glance
- LOINC
- 62347-0
- Short code
- Chrom analy prenatal pnl FISH
- Synonyms
- Chrom analy prenatal pnl FISH
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 44
- Ref high
- 147
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- fish
- CPT
- 84075
- SNOMED
- 27550007
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Prenatal chromosomal screening may be recommended if you’re at higher risk for conditions like Down syndrome, trisomy 13, or other genetic abnormalities. It can also be part of a routine check if you’re pregnant over 35 or have family history concerns.
How the Test Works
Blood is drawn to collect plasma or serum, which is then analyzed using advanced sequencing and fluorescent probes. This detects structural changes or missing/extra genetic material in specific chromosomes or genes.
Sample Preparation
You’ll need to fast for 8–12 hours before your blood draw, but hydration is encouraged. Avoid smoking or caffeine for 30 minutes before testing.
What to Expect During the Test
A healthcare provider will insert a needle into your arm to collect blood. The process takes about 5 minutes, and you may feel a brief pinch. Results are typically ready in 1–2 weeks.
Reference range
Adult: 44-147 U/LN/A
No special preparation required. Avoid fatty meals before the test if possible.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
This test identifies chromosomal abnormalities that could impact fetal development, such as missing or extra chromosomes (e.g., trisomy 21) or gene mutations linked to birth defects. Early detection allows for informed decision-making about prenatal care or interventions.
Short name
Prenatal chromosomal screening via NGS/FISH
Frequently asked questions
What are the most common conditions this test detects?
How does this differ from a standard amniocentesis or CVS test?
Can I get this test if I’m not at high risk?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy