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Chromosome Analysis Master Panel

Published: August 9, 2026Updated: August 17, 2026

A genetic testing panel that evaluates chromosome number and structure for conditions such as developmental delay, birth defects, or infertility.

Quick summary

["This panel can identify certain chromosome abnormalities that may help explain symptoms, guide care, or inform reproductive planning."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 17, 2026Editorial policy

Key facts at a glance

LOINC
62389-2
Short code
CHROMOSOMEANALYSISMASTERPANEL
Synonyms
—
Category
liver
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
10
Ref high
40
Critical range
— – 500 N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
84484
SNOMED
302774002
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What is this test?

Chromosome analysis examines the chromosomes in a sample of cells to look for differences in chromosome number or structure. A master panel may include several complementary genetic testing methods, so the exact tests included depend on the laboratory and the reason for ordering it.

Why might I need this test?

This testing may be considered for unexplained developmental concerns, multiple birth defects, unusual growth, delayed puberty, infertility, repeated pregnancy loss, or a family history of a chromosome condition. A genetic counselor or clinician can determine whether this panel is appropriate.

How is the test performed?

A laboratory examines chromosomes from patient cells, commonly obtained from a blood sample. The sample is cultured when required, and the chromosomes are analyzed using methods that may include karyotyping, chromosome microarray, or other testing specified by the panel. Special samples, such as amniotic fluid or chorionic villus samples, may be used for prenatal testing.

How do I prepare for the test?

For a routine blood chromosome analysis, fasting is generally not required unless the ordering laboratory gives different instructions. Follow any specimen-specific instructions, particularly for prenatal testing, and tell the care team if you have had a recent bone marrow transplant or received certain cellular therapies.

Reference range

Adult: 10-40 U/LN/A

Specimen: serum

No special preparation required. Avoid fatty meals before the test if possible.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

An abnormal result may show an extra or missing chromosome, a deleted or duplicated chromosome segment, a balanced rearrangement, or a mixture of cell lines with different chromosome patterns. These findings may help explain a condition or identify reproductive risk, but their meaning depends on the specific result and clinical history. A normal result does not exclude every genetic condition, including some small gene changes or multifactorial disorders, so results should be reviewed with a clinician or genetic counselor.

Short name

Chromosome analysis panel

Frequently asked questions

Does this test diagnose Down syndrome?
It can detect chromosome conditions involving an extra, missing, or rearranged chromosome, including trisomy 21, which is associated with Down syndrome. Other genetic tests may still be needed to evaluate developmental concerns if this panel is normal.
Can this test determine whether a chromosome finding came from a parent?
Sometimes. Parental testing may be recommended to clarify what a chromosome finding means or to assess the chance of a future pregnancy having the same finding. The ordering clinician or genetic counselor can arrange this if needed.
Will the results affect my insurance or employment?
Results are generally confidential and are shared with you and the ordering care team. Specific protections and limitations can vary by location and situation, so ask the healthcare provider or genetic counselor for guidance relevant to you.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy