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C-reactive protein (CRP) with high-sensitivity measurement (hs-CRP)

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein produced by the liver in response to inflammation, helping assess low-grade inflammation in your body.

Quick summary

["hs-CRP helps track subtle inflammation that may not show up in other tests."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
84918-2
Short code
Chr X aneup Amn/CVS Ql FISH
Synonyms
Chr X aneup Amn/CVS Ql FISH
Category
chemistry
Sample
fluid
Container
Sterile tube
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
fish
Specimen volume
2-5 mL
Stability
Room temperature: 2h, Refrigerated: 24h
Hemolysis max
300
TAT
4–24 hours
Order
routine

Why hs-CRP Matters

hs-CRP is a highly sensitive marker for inflammation, often used to monitor conditions like cardiovascular risk, autoimmune diseases, or chronic infections. It can help doctors detect inflammation before symptoms appear.

How It’s Used in Care

Your doctor may order hs-CRP to evaluate risk for heart disease, track response to treatments for conditions like rheumatoid arthritis, or monitor chronic conditions like diabetes or kidney disease.

How the Test Works

A small blood sample is taken to measure hs-CRP levels using a sensitive immunoassay method. This test helps identify inflammation even when it’s not severe.

What to Expect

You’ll receive results in a few days, often alongside other lab tests. Your doctor will interpret results in the context of your overall health.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: hs-CRP is a key tool for identifying inflammation-related risks. Elevated levels may signal increased cardiovascular risk, while low levels suggest reduced inflammation. It’s particularly useful for monitoring chronic conditions where inflammation plays a role.

Short name

hs-CRP

Frequently asked questions

What does an elevated hs-CRP level mean?
An elevated hs-CRP level may indicate inflammation in your body, which could be linked to conditions like heart disease, infections, or autoimmune disorders. Your doctor will discuss results with you and may recommend lifestyle changes or further testing.
How often should I get this test?
Your doctor will determine how often you need hs-CRP testing based on your health history, symptoms, and other risk factors. It’s often used periodically for monitoring, not as a routine annual test.
Can lifestyle changes lower hs-CRP levels?
Yes! Reducing stress, improving diet (rich in fruits, vegetables, and omega-3s), staying active, and avoiding smoking can help lower inflammation and hs-CRP levels over time.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy