Cerebrospinal Fluid Myelin Basic Protein (MBP) Concentration

Why This Test Might Be Ordered

Your doctor may recommend this test if you have symptoms like numbness, weakness, or balance issues that could suggest a condition affecting the brain or spinal cord, such as multiple sclerosis (MS) or other demyelinating diseases. It may also be used to monitor progression or response to treatment in certain cases.

What to Expect Before the Test

You’ll have a lumbar puncture (spinal tap) where a small needle is inserted into your lower back to collect CSF. This procedure is usually quick and done while you’re lying on your side. You may feel mild pressure or discomfort, but it’s temporary.

What the Results Mean

Elevated levels of MBP in CSF can suggest demyelination (loss of myelin) in the central nervous system, which is common in conditions like multiple sclerosis. However, results alone aren’t diagnostic; they’re often interpreted alongside other clinical findings and imaging.

Common Conditions Linked to Abnormal Results

High MBP levels may be associated with demyelinating diseases, such as multiple sclerosis, neuromyelitis optica, or other inflammatory or infectious processes affecting the CNS. Low or normal levels don’t rule out these conditions entirely.