Cerebrospinal Fluid Myelin Basic Protein (MBP) by Immunoassay

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like numbness, weakness, or vision changes that could suggest conditions like multiple sclerosis (MS), neuromyelitis optica (NMO), or other inflammatory or demyelinating diseases of the central nervous system. It may also be used to monitor disease progression or response to treatment.

What to Expect Before the Test

You’ll have a lumbar puncture (spinal tap) where a small amount of CSF is collected from your lower back. This procedure is usually done in a hospital or clinic setting. You may feel mild pressure afterward, but it’s generally not painful. No special preparation is typically needed, but inform your doctor about any medications you’re taking.

What the Test Results Mean

Elevated levels of MBP in CSF can indicate active inflammation or demyelination in the central nervous system. However, results alone aren’t diagnostic—they’re often interpreted alongside clinical symptoms, imaging studies, and other tests. Your doctor will discuss the results with you in detail.

Common Conditions Monitored

This test is commonly used to diagnose or monitor conditions such as multiple sclerosis, neuromyelitis optica spectrum disorder (NMOSD), acute disseminated encephalomyelitis (ADEM), or other demyelinating diseases. It may also help assess the extent of nerve damage in certain neurological conditions.