Skip to content

C-reactive protein (CRP) in serum/plasma

Published: August 9, 2026Updated: August 16, 2026

This test measures the level of C-reactive protein, a protein produced by the liver in response to inflammation or infection in your body.

Quick summary

["CRP helps doctors assess inflammation and identify possible infections or conditions causing swelling."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
31048-2
Short code
C immitis Ab Fld Ql CF
Synonyms
C immitis Ab Fld Ql CF
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
comp-fix
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is C-Reactive Protein Used For?

CRP is commonly used to monitor inflammation in conditions like arthritis, heart disease, or after surgery. It can also help detect infections, such as pneumonia or urinary tract infections, especially in people with weakened immune systems. Some doctors use it to track how well treatments are working for chronic inflammatory diseases.

Why Might You Need This Test?

Your doctor may order a CRP test if you have symptoms of inflammation, such as fever, pain, or swelling, or if you’re at risk for conditions like heart disease or autoimmune disorders. It’s also used in certain screening or follow-up situations, like after a heart attack or before surgery.

How Is the Test Done?

A blood sample is taken from a vein, usually in your arm. The blood is sent to a lab where it’s analyzed to measure CRP levels. The test typically takes a few hours to complete, and results are usually available within a day or two.

What Do My Results Mean?

Results can vary widely depending on your health status. Very high levels may indicate severe inflammation or infection, while very low levels might suggest no active inflammation. Your doctor will interpret the results in the context of your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: CRP plays a key role in identifying and monitoring inflammation across many diseases. It’s a useful marker for guiding treatment decisions, assessing disease activity, and evaluating response to therapy in conditions like rheumatoid arthritis, cardiovascular disease, or sepsis. However, it’s not always definitive on its own and is often used alongside other tests.

Short name

CRP (Serum/Plasma)

Frequently asked questions

What causes CRP levels to be high?
High CRP levels can be caused by infections (like pneumonia or urinary tract infections), inflammatory diseases (such as arthritis or inflammatory bowel disease), injuries, or certain medical conditions like heart disease or autoimmune disorders. Stress or certain medications can also temporarily affect CRP levels.
How often should I get this test?
The frequency depends on your doctor’s recommendations. Some people get CRP tests regularly if they have chronic conditions like heart disease or arthritis, while others may only need it if they have symptoms or specific medical reasons. Always follow your doctor’s advice.
Can CRP levels be affected by diet or lifestyle?
Yes, diet and lifestyle can influence CRP levels. Eating a healthy, anti-inflammatory diet (rich in fruits, vegetables, and omega-3 fatty acids) may help lower CRP levels, while smoking, excessive alcohol, or obesity can increase them. Regular physical activity is also linked to lower CRP levels.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy