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Anti-Mitochondrial Antibody (Mitochondrial Antibody) – Serum

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies that target mitochondrial proteins, often linked to primary biliary cholangitis (PBC), a rare autoimmune liver disease.

Quick summary

["Helps diagnose or monitor autoimmune liver conditions by detecting specific immune responses."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
5094-8
Short code
C immitis Ab Ser IA-aCnc
Synonyms
C immitis Ab Ser IA-aCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test if you have symptoms like itching, fatigue, or jaundice, or if they suspect an autoimmune liver disease. It’s also used to confirm or track PBC progression or response to treatment.

What to Expect Before the Test

No special preparation is needed. A blood sample is drawn from a vein, usually in your arm. You may feel a slight pinch, but it’s quick and painless.

What the Results Mean

Positive results suggest a high likelihood of PBC or other autoimmune liver conditions. However, false positives can occur, so results are often interpreted alongside clinical findings and other tests.

Common Conditions Linked to Positive Results

A positive test is most strongly associated with primary biliary cholangitis (PBC), but it can also appear in other autoimmune liver diseases or rare cases of other conditions.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Autoimmune Liver Disease Detection

Short name

Anti-Mitochondrial Antibody (AMAb)

Frequently asked questions

What symptoms might I have if my test results are positive?
Symptoms of PBC or related conditions may include persistent itching (especially in the palms and soles), fatigue, jaundice (yellowing of skin/eyes), dark urine, pale stools, or weight loss. Not everyone with a positive test will have symptoms, so your doctor will assess your overall health.
Can this test be used to monitor my condition over time?
Yes, this test can help monitor PBC or other autoimmune liver diseases. Your doctor may repeat it to track changes in your immune response or liver function, especially if you’re undergoing treatment.
Are there any risks or side effects from this blood test?
The most common side effect is a slight bruise, redness, or swelling at the injection site. Rarely, you might experience dizziness or fainting due to the needle. Most people tolerate the test well.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy