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Serum Immunoassay for Anti-Mitochondrial Antibodies (AMA-Specific)

Published: August 9, 2026Updated: August 16, 2026

This test measures antibodies directed against mitochondrial proteins in your blood, often used to diagnose primary biliary cholangitis (PBC).

Quick summary

["Helps identify liver disease linked to autoimmune attacks on bile ducts."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
31782-6
Short code
C immitis Ag Islt Ql
Synonyms
C immitis Ag Islt Ql
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Is Primary Biliary Cholangitis?

Primary biliary cholangitis (PBC) is a chronic autoimmune liver disease where your immune system mistakenly attacks bile ducts in your liver. Over time, this can lead to liver damage, inflammation, and potential complications like cirrhosis or liver failure. The AMA test helps confirm this diagnosis by detecting specific antibodies linked to PBC.

Why Is This Test Ordered?

Your healthcare provider may order this test if you have symptoms like fatigue, itching, jaundice (yellow skin/eyes), or unexplained liver test abnormalities. It’s also used to monitor disease progression or response to treatment in confirmed PBC cases.

What to Expect Before the Test

No special preparation is needed. A blood sample is drawn from a vein, usually in your arm. You may feel slight discomfort, but it’s quick and painless. Avoid alcohol for 24 hours before testing if advised by your doctor.

What Are Possible Results?

Results are qualitative (positive/negative) for AMA antibodies. A positive result strongly suggests PBC, but further testing (like liver function tests or bile duct imaging) may be needed to confirm diagnosis and guide treatment.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

AMA-Serum Test

Frequently asked questions

What Does a Positive Result Mean?
A positive result strongly suggests PBC, but your doctor will review all test results and symptoms to confirm the diagnosis. You may need additional tests to rule out other liver conditions or to monitor disease activity.
What If I Have Symptoms Like Itching or Fatigue?
These symptoms are common in PBC. If you have them, discuss your test results with your doctor. They may recommend lifestyle changes (like a low-fat diet), medications to control itching or liver function, or referrals to a liver specialist.
Can This Test Be Used to Track Disease Progress?
Yes, your doctor may order this test periodically to monitor changes in your AMA levels. While AMA levels don’t always fluctuate with disease activity, they can help track overall liver health and response to treatment over time.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy