Cerebrospinal Fluid Immunoglobulin Free Light Chain Profile (kappa and lambda)

Why This Test Is Done

Your doctor may order this test if they suspect conditions like multiple myeloma, lymphoma, or other cancers that affect plasma cells. It’s also used to check for signs of inflammation, infections, or other neurological issues linked to abnormal protein production in the CSF.

What to Expect Before the Test

You’ll receive a spinal tap (lumbar puncture) under sterile conditions. The doctor will insert a needle into your lower back to collect CSF. You may feel mild pressure or discomfort, but it’s usually brief. No special preparation is needed beyond being hydrated and resting afterward.

What the Results Mean

Results show the presence and levels of kappa and lambda free light chains in your CSF. Elevated or imbalanced levels may indicate conditions like plasma cell dyscrasias, infections, or other neurological disorders. Your doctor will interpret results in the context of your symptoms and medical history.

Common Conditions Monitored

This test helps diagnose or monitor multiple myeloma, primary central nervous system lymphoma, and other plasma cell disorders. It may also be used to evaluate symptoms like headaches, neurological deficits, or unexplained CSF abnormalities.