Cerebrospinal Fluid Myelin Basic Protein (MBP) Concentration

Why This Test Might Be Ordered

Your healthcare provider may recommend this test if you have symptoms like numbness, weakness, vision changes, or balance issues that could suggest a condition affecting the central nervous system, such as multiple sclerosis or other demyelinating diseases. It may also be used to monitor progression or response to treatment in certain cases.

What to Expect Before the Test

You’ll need a lumbar puncture (spinal tap), where a small needle is inserted into your lower back to collect CSF. This procedure is usually done in a hospital setting and may cause temporary discomfort. No special preparation is typically required, but inform your provider about any medications you’re taking.

What the Results Mean

Elevated levels of myelin basic protein in CSF can indicate nerve damage or demyelination, though results alone aren’t diagnostic. Your provider will interpret the results in the context of your symptoms, medical history, and other tests. Normal results suggest no significant myelin breakdown.

Common Conditions Monitored

This test is often used to evaluate conditions like multiple sclerosis, optic neuritis, transverse myelitis, or other inflammatory or degenerative diseases affecting the central nervous system.