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C-Reactive Protein (High-Sensitivity) with Immunoassay Method

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein in your blood that rises when inflammation is present, often used to check for low-grade inflammation or infection.

Quick summary

["hs-CRP helps track subtle inflammation that may not show up with other tests."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
110058-5
Short code
C immitis IgM Msmt Ser
Synonyms
C immitis IgM Msmt Ser
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may order this test to monitor chronic conditions like heart disease, arthritis, or autoimmune disorders, or to check for signs of inflammation after surgery, injury, or infection. It can also help assess risk for future health problems like heart attacks or strokes.

What to Expect Before the Test

No special preparation is needed. You’ll have a small needle inserted into your arm to draw blood. It usually takes about 15 minutes. Avoid strenuous activity or heavy meals 2 hours before the test if instructed.

What the Test Results Mean

Results are compared to a general reference range, but exact values can vary by lab. Higher levels may indicate inflammation, infection, or other health issues. Very low levels might suggest no active inflammation.

Common Conditions Monitored

This test is often used to evaluate conditions such as cardiovascular risk, rheumatoid arthritis, or to monitor response to treatments for inflammation-related diseases.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

hs-CRP (serum)

Frequently asked questions

What does a high hs-CRP level mean?
A high hs-CRP level suggests your body is experiencing inflammation, which could be due to infection, injury, or underlying health conditions like heart disease or arthritis. Your doctor will discuss the results with you and may recommend further testing or lifestyle changes.
Can diet or exercise affect hs-CRP levels?
Yes, lifestyle factors like diet, exercise, and weight can influence inflammation levels. Eating a heart-healthy diet, staying active, and maintaining a healthy weight may help lower hs-CRP levels over time.
Is hs-CRP the same as CRP?
Yes, hs-CRP is a high-sensitivity version of the C-Reactive Protein test, allowing for more precise detection of low-level inflammation in the blood.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy