Serum Creatinine Kinase (CK) Isoenzyme Subtype Analysis (CK-MB, CK-MM, CK-Total)
This test measures different forms of Creatine Kinase (CK), an enzyme that helps muscles and the heart produce energy. It helps identify which muscle type is affected if you have symptoms like muscle pain, weakness, or heart issues.
["Assess muscle or heart damage by identifying specific CK isoenzymes."]
Key facts at a glance
- LOINC
- 47026-0
- Short code
- CK HMW Ag Tiss Ql ImStn
- Synonyms
- CK HMW Ag Tiss Ql ImStn
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 22
- Ref high
- 198
- Critical range
- — – 10000 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- immune-stain
- CPT
- 82553
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
Why This Test Matters
CK is found in both heart and skeletal muscles. Different isoenzymes (CK-MB for heart, CK-MM for muscles) can indicate where damage is occurring. For example, high CK-MB levels often signal heart muscle injury, while elevated CK-MM may point to muscle disorders or injury.
When You Might Need It
Your doctor may order this test if you have symptoms like chest pain, muscle weakness, or unexplained fatigue. It’s also used after heart attacks, muscle injuries, or conditions like myositis (inflammation of muscles).
What to Expect Before the Test
No special preparation is needed, but you may be asked to fast for 8–12 hours if your blood is drawn early in the morning. Wear loose clothing for easy access to your arm.
During the Test
A healthcare provider will insert a small needle into a vein in your arm to draw blood. This usually takes a few minutes. You may feel a slight pinch, but it’s quick and not painful.
Reference range
Adult males: 22-198 U/L; Females: 22-198 U/LN/A
No special preparation required. Inform provider of any chest pain or symptoms.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Elevated CK levels or specific isoenzyme patterns can signal muscle damage, heart problems, or other conditions like myopathy (muscle disease). For example, CK-MB spikes often confirm a heart attack, while very high CK-MM levels may indicate muscle disorders like rhabdomyolysis (severe muscle breakdown). Always discuss results with your doctor, as they’ll interpret them in the context of your symptoms and medical history.
Short name
CK Isoenzyme Profile
Frequently asked questions
How long does it take to get results?
What causes abnormal CK levels?
Can I exercise before this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy