Creatinine Kinase, Total (Serum/Plasma)
This test measures the total amount of Creatinine Kinase, an enzyme produced by heart, skeletal muscle, and brain cells. It helps assess damage to these tissues.
["Evaluates muscle, heart, or brain injury risk by tracking enzyme levels released during cell damage."]
Key facts at a glance
- LOINC
- 26020-8
- Short code
- CK Macro2 CFr SerPl
- Synonyms
- CK Macro2 CFr SerPl
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 22
- Ref high
- 198
- Critical range
- — – 10000 N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82553
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What Is Creatinine Kinase Used For?
Creatinine kinase (CK) is released into the bloodstream when muscle, heart, or brain cells are damaged. Elevated levels may signal conditions like heart attacks, muscle injuries, or neurological events. This test is often used to monitor symptoms of muscle weakness, chest pain, or unexplained fatigue.
Common Conditions Monitored
High CK levels can indicate acute muscle injury (e.g., from exercise, trauma), heart-related issues (e.g., myocardial infarction), or neurological disorders (e.g., stroke). Chronic elevations may suggest underlying conditions like myopathies or mitochondrial disorders.
When Might You Need This Test?
Your doctor may order this test if you experience unexplained muscle pain, weakness, chest discomfort, or symptoms like dizziness or confusion. It’s also used in research or follow-up for conditions like heart disease or muscle disorders.
What to Expect Before the Test
No special preparation is needed, but avoid strenuous exercise or heavy lifting 24 hours before testing. If you’re on blood thinners or have recent trauma, inform your provider to avoid unnecessary stress on muscles.
Reference range
Adult males: 22-198 U/L; Females: 22-198 U/LN/A
No special preparation required. Inform provider of any chest pain or symptoms.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
Total CK (Serum/Plasma)
Frequently asked questions
Why might my CK levels be elevated?
What do low CK levels mean?
How often will I need this test?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 17, 2026. · Read our editorial policy