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Lymph Node Fluid Protein Electrophoresis (Lymph Node Fluid Protein Profile)

Published: August 9, 2026Updated: August 16, 2026

This test analyzes the protein composition in fluid collected from a lymph node biopsy, often used to diagnose conditions like lymphoma or other lymphoproliferative disorders.

Quick summary

["Helps identify abnormal protein patterns that may signal cancer or immune system issues."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
30419-6
Short code
Cleft Lymphs NFr Bld
Synonyms
Cleft Lymphs NFr Bld
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your healthcare provider may recommend this test if you have symptoms like unexplained lymph node swelling, weight loss, night sweats, or fatigue. It may also be used to monitor treatment progress or confirm a suspected diagnosis of lymphoma or other lymph node-related disorders.

What to Expect Before the Test

You’ll undergo a biopsy where fluid is collected from a swollen lymph node under local anesthesia. The procedure is quick but may cause mild discomfort. Bring any medications you’re taking and let your provider know about allergies or recent infections.

What Happens During the Test

The collected fluid is sent to a lab where proteins are separated using electrophoresis. This process helps identify abnormal protein bands that could indicate conditions like monoclonal gammopathy or other protein abnormalities.

What the Results Mean

Results show the types and amounts of proteins in the fluid. Abnormal patterns may suggest lymphoma, leukemia, or other disorders affecting the immune system. Your provider will interpret results in the context of your symptoms and medical history.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

This test is critical for diagnosing and staging lymphomas, such as Hodgkin’s or non-Hodgkin’s lymphoma. It may also help differentiate between benign and malignant conditions by revealing specific protein signatures in lymph node fluid.

Short name

Lymph Node Fluid Protein Electrophoresis

Frequently asked questions

How long does it take to get results from this test?
Results are typically available within 1–3 business days, depending on lab processing times. Your provider will discuss findings with you during a follow-up visit.
What are common reasons for performing this test?
Common reasons include suspected lymphoma, unexplained lymph node enlargement, or evaluating symptoms like persistent fatigue, weight loss, or fever of unknown origin.
Is this test painful?
The biopsy procedure may cause mild discomfort, but local anesthesia ensures the area is numb. Most patients report minimal pain afterward.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy