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: Clinical Signs of Congenital Syphilis

Published: August 9, 2026Updated: August 16, 2026

: This test documents whether an infant shows physical signs consistent with congenital syphilis, a syphilis infection passed from mother to baby during pregnancy or birth.

Quick summary

: Recognizing physical signs of congenital syphilis helps clinicians decide on further testing and early treatment.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
75193-3
Short code
CLINICALSIGNSOFCONGENITALSYPHILIS
Synonyms
—
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
cdc-cs
CPT
86592
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

: What This Assessment Is

: Congenital syphilis occurs when the bacterium that causes syphilis is transmitted from a pregnant person to the fetus. This entry captures the clinical (physical) signs a clinician observes during examination of the infant, rather than a laboratory measurement.

: Signs Clinicians Look For

: Healthcare providers examine the baby for findings that may include rash, jaundice, nasal discharge, bone or joint changes, enlarged liver or spleen, and other abnormalities. Because signs can be subtle or absent at birth, a thorough physical exam is important.

: How It Fits With Other Tests

: Physical findings are considered together with the mother's syphilis test results and the infant's own blood tests, such as serology and other laboratory studies. No single sign or test confirms the diagnosis on its own.

: What Happens Next

: If signs are present or risk is high, the care team may recommend additional testing and treatment. Early identification and treatment generally lead to better outcomes for the infant.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

: Documenting clinical signs of congenital syphilis supports timely diagnosis and treatment. Because many affected infants appear normal at birth, this assessment is used alongside maternal history and laboratory testing to guide management.

Short name

: Congenital Syphilis Signs

Frequently asked questions

: Does a normal physical exam rule out congenital syphilis?
: No. Many infants with congenital syphilis have no obvious signs at birth, so examination is combined with maternal history and laboratory testing.
: Is this the same as a blood test for syphilis?
: No. This describes the physical examination findings; blood tests are separate laboratory evaluations that measure the body's response to infection.
: Why is early recognition important?
: Early treatment of congenital syphilis can prevent serious complications, so clinicians act promptly when signs or risk factors are present.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy