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Clonal Frequency in Peripheral Blood (Flow Cytometry)

Published: August 9, 2026Updated: August 16, 2026

This test measures the proportion of abnormal (cloned) cells in your blood, often used to evaluate conditions like leukemia or lymphoma.

Quick summary

["Assists doctors in diagnosing and monitoring blood cancers or immune disorders by identifying abnormal cell populations."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
107554-8
Short code
Clonal frequency NFr Bld/T
Synonyms
Clonal frequency NFr Bld/T
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
molgen
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

Why This Test Matters

Clonal cells are identical copies of a single abnormal cell that may develop in conditions such as blood cancers (e.g., leukemia, myeloma) or certain immune disorders. This test helps determine if these cells are present in your bloodstream.

How the Test Works

A small sample of your blood is analyzed using flow cytometry, a technique that separates and counts different cell types based on their size, shape, and surface markers. Special fluorescent dyes highlight cloned cells for detection.

Sample Collection and Preparation

Blood is drawn from a vein, typically in your arm. The sample is processed to identify and count clonal cells, which may appear different from normal blood cells under a microscope.

What to Expect Before the Test

No special preparation is needed, but you may be asked to avoid certain medications or supplements that could interfere with results. Bring any recent blood work or medical records if requested.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Clonal Blood Cell Count

Frequently asked questions

How long does it take to get results?
Results are usually available within 1–3 business days, depending on lab processing times. Your healthcare provider will discuss findings with you during your follow-up visit.
What does a high clonal frequency mean?
A high clonal frequency often suggests the presence of a blood cancer or clonal disorder, such as leukemia or lymphoma. Your doctor will interpret results in the context of your symptoms, medical history, and other tests.
Can diet or supplements affect this test?
No specific diet or supplements are known to interfere with clonal frequency testing, but avoid blood-thinning medications (e.g., warfarin) or supplements (e.g., high-dose vitamin E) without approval from your doctor before testing.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy