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C-reactive protein (CRP) by high-performance liquid chromatography (HPLC) or nephelometry

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein called C-reactive protein, which your body produces in response to inflammation. It helps doctors assess whether you have low-grade inflammation that may be affecting your health.

Quick summary

["High sensitivity CRP helps detect subtle inflammation linked to conditions like heart disease or autoimmune disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
88567-3
Short code
CMV DNA Mar Ql NAA+probe
Synonyms
CMV DNA Mar Ql NAA+probe
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
probe-amp-tar
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why This Test Is Done

Your doctor may order this test to monitor chronic inflammation, evaluate risk for cardiovascular events, or check for signs of inflammation in conditions like rheumatoid arthritis, lupus, or other autoimmune diseases. High sensitivity CRP is often used in people with no obvious symptoms but a higher risk of heart problems.

What to Expect Before the Test

No special preparation is needed. You may have a blood sample drawn from a vein in your arm. If you’re taking blood thinners, let your doctor know before the test.

How the Test Works

Blood is drawn and analyzed using either HPLC or nephelometry to measure CRP levels. CRP rises when your body detects inflammation, but it doesn’t identify the cause.

What the Results Mean

Results are reported in milligrams per liter (mg/L). Higher levels may indicate inflammation, but they don’t pinpoint the reason. Your doctor will interpret results in the context of your overall health and symptoms.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

CRP (High Sensitivity)

Frequently asked questions

What causes CRP levels to change?
CRP levels can rise due to infections, injuries, autoimmune diseases, or other inflammatory conditions. They may also temporarily increase after surgery, illness, or stress. Smoking, obesity, and certain medications can also affect CRP levels.
How long does it take to get results?
Results are typically available within 24 to 48 hours, depending on your lab’s processing time. Your doctor will discuss the results with you during your follow-up visit.
Can lifestyle changes affect CRP levels?
Yes, lifestyle factors like diet, exercise, smoking, and weight can influence CRP levels. Reducing inflammation through diet, regular activity, and avoiding smoking may help lower CRP over time.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy