Cell-free Tumor DNA (ctDNA) Analysis for [Specific Gene Mutation] Detection (e.g., EGFR, BRAF, KRAS)
This test checks for specific genetic mutations in tiny DNA fragments released by cancer cells into your bloodstream. It helps determine if cancer is present, how it may respond to treatment, or if it has spread.
["A non-invasive way to monitor cancer genetics through your blood."]
Key facts at a glance
- LOINC
- 54163-1
- Short code
- CMV DNA # Ur NAA DL=200
- Synonyms
- CMV DNA # Ur NAA DL=200
- Category
- chemistry
- Sample
- urine
- Container
- Sterile urine container
- Units
- N/A
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- Method
- probe-amp-tar-detection-limit-copies-ml
- Specimen volume
- 10 mL
- Stability
- Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
Why This Test Is Done
Doctors may order this test if you have a known cancer history, are at high risk for certain cancers, or are undergoing treatment to check for resistance or recurrence. It can also guide personalized treatment decisions by identifying specific genetic changes in your tumor DNA.
How the Test Works
A small blood sample is taken. The lab extracts cell-free DNA from your plasma and analyzes it for known mutations in genes linked to cancer. Advanced techniques like next-generation sequencing identify these mutations with high precision.
Sample Collection and Preparation
No special preparation is needed, but fasting may be advised depending on the lab’s protocol. You’ll have a simple blood draw, similar to a routine blood test. The sample is processed to isolate DNA from cancer cells.
What to Expect After the Test
Results are typically ready within 1–2 weeks. Your healthcare provider will discuss findings, including whether mutations were detected and their potential implications for treatment. Follow-up may include additional tests or treatment adjustments.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Positive results identifying specific mutations can direct targeted therapies, such as tyrosine kinase inhibitors for EGFR mutations or BRAF inhibitors for BRAF mutations. Negative results may confirm no detectable mutations in this sample, but cancer could still be present elsewhere. This test is most useful when combined with other diagnostic tools.
Short name
ctDNA Mutation Screening
Frequently asked questions
What does a positive result mean?
Can this test detect all types of cancer?
Is this test covered by insurance?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy