Cytomegalovirus (CMV) IgG Antibody, Serum

Why This Test Might Be Ordered

Your healthcare provider may order this test if you have symptoms of CMV infection, such as fever, fatigue, or swollen lymph nodes, or if you’re at higher risk for complications from CMV, like organ transplant recipients or people with weakened immune systems. It can also be used to screen for past exposure before certain procedures or treatments.

What to Expect Before the Test

No special preparation is needed. You’ll provide a blood sample, usually drawn from a vein in your arm. The test involves minimal discomfort and typically takes a few minutes. If you’re pregnant or have a bleeding disorder, let your provider know before the test.

What the Results Mean

A positive result means you have antibodies to CMV, suggesting past infection and immunity. A negative result means you likely haven’t been exposed recently, but this doesn’t rule out past exposure. Results can vary based on your medical history and immune status.

Common Reasons for Testing

This test is often used in transplant patients to check for CMV before receiving an organ to prevent infection. It may also be used in pregnant women to assess risk of congenital CMV infection in the baby or in people with HIV to monitor CMV activity.