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C-reactive protein, serum/plasma concentration (high-sensitivity)

Published: August 9, 2026Updated: August 16, 2026

This test measures a protein in your blood that rises when your body is fighting inflammation or infection.

Quick summary

["hs-CRP helps track inflammation, often used alongside other tests to assess risk for conditions like heart disease."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
87726-6
Short code
CMV IgG SerPl Donr Ql IA
Synonyms
CMV IgG SerPl Donr Ql IA
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
ia
CPT
82784
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

Why Is This Test Done?

Your doctor may order hs-CRP to monitor chronic conditions like arthritis or heart disease, check for signs of infection, or evaluate inflammation after surgery or injury. It can also help assess risk for future health problems, such as heart attacks or strokes, especially in people with risk factors like high blood pressure or diabetes.

What to Expect Before the Test

No special preparation is needed. You may have a small needle inserted into your arm or a blood sample drawn from a vein. If you’re on blood thinners, let your doctor know before the test.

What the Results Mean

Results are not given as a single number but as a range (e.g., low, normal, or high). Higher levels may indicate inflammation, infection, or other health concerns. Your doctor will interpret results in the context of your overall health and medical history.

Common Causes of Elevated Levels

Infections (bacterial, viral, or fungal), autoimmune diseases (like rheumatoid arthritis), heart disease, kidney disease, or recent surgery or trauma can raise hs-CRP levels. Smoking, obesity, or stress may also contribute.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

hs-CRP

Frequently asked questions

What does a high hs-CRP level mean?
A high hs-CRP level suggests your body is actively fighting inflammation or infection. This could be due to an ongoing condition like arthritis, a recent injury, or an infection. Your doctor will review the result with your other health information to determine the next steps.
Can lifestyle changes lower hs-CRP levels?
Yes! Reducing smoking, improving diet (rich in fruits, vegetables, and whole grains), staying physically active, and managing stress may help lower inflammation over time. Ask your doctor about personalized recommendations.
How often should I get this test?
Your doctor will decide how often to check your hs-CRP based on your health needs. For example, people with heart disease may get it more frequently to monitor progress or adjust treatments. Follow-up schedules vary by individual.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy