Total Carbon Dioxide in Blood (as Bicarbonate)
This test measures the amount of carbon dioxide in your blood, primarily in the form of bicarbonate, which helps regulate your body’s acid-base balance.
["Your blood’s bicarbonate levels help maintain healthy pH and support normal breathing and metabolism."]
Key facts at a glance
- LOINC
- 16551-4
- Short code
- CO2 BldC-sCnc
- Synonyms
- CO2 BldC-sCnc
- Category
- chemistry
- Sample
- whole-blood
- Container
- Lavender-top (EDTA)
- Units
- N/A
- Ref low
- 22
- Ref high
- 28
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82374
- Specimen volume
- 3 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h
- Hemolysis max
- 0
- Lipemia max
- 0
- Icterus max
- 0
- TAT
- 4–24 hours
- Order
- routine
What Does This Test Measure?
Total CO₂ in your blood is a key indicator of how well your body is balancing acidity and alkalinity. It reflects the amount of carbon dioxide converted into bicarbonate, which is a critical part of your body’s natural buffering system. This test is often used alongside other blood gas measurements to assess respiratory and metabolic health.
Why Might This Test Be Ordered?
Doctors may order this test if you have symptoms like shortness of breath, fatigue, or signs of acid-base imbalances (such as rapid breathing, confusion, or muscle weakness). It’s also used in monitoring conditions like chronic obstructive pulmonary disease (COPD), kidney disease, or metabolic disorders.
How Is This Test Performed?
A small blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab where it’s analyzed to measure the total carbon dioxide content, primarily as bicarbonate. No special preparation is needed, but fasting may be required depending on the clinical context.
What Are Common Results and Their Meanings?
Results are typically reported as a numerical value (e.g., mmol/L) that reflects the concentration of total CO₂ in your blood. While reference ranges can vary by lab, higher or lower levels may signal potential issues like respiratory or metabolic disorders.
Reference range
Adult: 22-28 mmol/LN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance: Understanding Your Results
Short name
Total CO₂ (Serum)
Frequently asked questions
How Long Does It Take to Get Results?
What If My Results Are Outside the Normal Range?
Does This Test Require Any Special Preparation?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy