Skip to content

Total Carbon Dioxide in Blood (as Bicarbonate)

Published: August 9, 2026Updated: August 16, 2026

This test measures the amount of carbon dioxide in your blood, primarily in the form of bicarbonate, which helps regulate your body’s acid-base balance.

Quick summary

["Your blood’s bicarbonate levels help maintain healthy pH and support normal breathing and metabolism."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
16551-4
Short code
CO2 BldC-sCnc
Synonyms
CO2 BldC-sCnc
Category
chemistry
Sample
whole-blood
Container
Lavender-top (EDTA)
Units
N/A
Ref low
22
Ref high
28
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82374
Specimen volume
3 mL
Stability
Room temperature: 4h, Refrigerated: 24h
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Does This Test Measure?

Total CO₂ in your blood is a key indicator of how well your body is balancing acidity and alkalinity. It reflects the amount of carbon dioxide converted into bicarbonate, which is a critical part of your body’s natural buffering system. This test is often used alongside other blood gas measurements to assess respiratory and metabolic health.

Why Might This Test Be Ordered?

Doctors may order this test if you have symptoms like shortness of breath, fatigue, or signs of acid-base imbalances (such as rapid breathing, confusion, or muscle weakness). It’s also used in monitoring conditions like chronic obstructive pulmonary disease (COPD), kidney disease, or metabolic disorders.

How Is This Test Performed?

A small blood sample is drawn from a vein, usually in your arm. The sample is sent to a lab where it’s analyzed to measure the total carbon dioxide content, primarily as bicarbonate. No special preparation is needed, but fasting may be required depending on the clinical context.

What Are Common Results and Their Meanings?

Results are typically reported as a numerical value (e.g., mmol/L) that reflects the concentration of total CO₂ in your blood. While reference ranges can vary by lab, higher or lower levels may signal potential issues like respiratory or metabolic disorders.

Reference range

Adult: 22-28 mmol/LN/A

Specimen: whole-blood

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance: Understanding Your Results

Short name

Total CO₂ (Serum)

Frequently asked questions

How Long Does It Take to Get Results?
Test results are usually available within 24 to 48 hours, depending on lab processing times. Your healthcare provider will discuss the results with you during your follow-up visit.
What If My Results Are Outside the Normal Range?
If your results are abnormal, your doctor may recommend further testing or adjustments to your treatment plan. This could include additional blood tests, imaging, or lifestyle changes to address the underlying cause.
Does This Test Require Any Special Preparation?
Most often, no special preparation is needed, but your doctor may instruct you to avoid certain foods or activities before the test if it’s part of a broader evaluation (e.g., fasting for metabolic studies). Always follow your provider’s specific instructions.
  1. 1
  2. 2
  3. 3

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy