Carbon Dioxide in Blood (as Bicarbonate and Carbonic Acid)
This test measures the amount of carbon dioxide in your blood, primarily in the form of bicarbonate, which helps regulate your body’s acid-base balance.
["Your blood’s CO₂ levels help maintain healthy pH and support normal breathing and kidney function."]
Key facts at a glance
- LOINC
- 14640-7
- Short code
- CO2 Dial fld-sCnc
- Synonyms
- CO2 Dial fld-sCnc
- Category
- chemistry
- Sample
- serum
- Container
- Red-top tube (SST)
- Units
- N/A
- Ref low
- 22
- Ref high
- 28
- Fasting
- false
- Population
- adult
- Sex
- all
- Age range
- 18–65 years
- CPT
- 82374
- Specimen volume
- 5 mL
- Stability
- Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
- Hemolysis max
- 500
- Lipemia max
- 1000
- Icterus max
- 500
- TAT
- 4–24 hours
- Order
- routine
What This Test Measures
Blood gases, including CO₂, are critical for keeping your body’s chemistry stable. Your blood carries carbon dioxide from tissues to the lungs, where it’s exhaled. This test checks the total CO₂ content, which includes bicarbonate (a key buffer) and carbonic acid (formed when CO₂ dissolves in blood).
Why It Matters in Your Health
Abnormal CO₂ levels can signal conditions like respiratory issues (e.g., asthma, COPD), metabolic problems (e.g., kidney disease, diabetes), or fluid imbalances. High levels may indicate overproduction of CO₂ (e.g., hyperventilation), while low levels could suggest breathing difficulties or metabolic acidosis.
Common Conditions Affecting Results
This test is often ordered when you have symptoms like shortness of breath, chest pain, confusion, or rapid heartbeat. It may also be used to monitor chronic conditions like heart failure, kidney disease, or severe infections.
Sample Collection and Preparation
A blood sample is taken from a vein (usually in your arm) and sent to a lab for immediate analysis. No special preparation is needed, but fasting may be required depending on the clinical context.
Reference range
Adult: 22-28 mmol/LN/A
No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.
Clinical interpretation
How abnormal results are interpreted and what conditions they suggest.
Clinical Significance
Short name
CO₂ (blood gas)
Frequently asked questions
How does CO₂ testing help doctors diagnose health issues?
Can diet or medications affect this test?
What if my results are outside the normal range?
Sources
- 1
- 2Lab Tests OnlineSource
- 3
Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy