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Carbon Dioxide (Total) in Blood Gas Analysis

Published: August 9, 2026Updated: August 16, 2026

This test measures the total amount of carbon dioxide in your blood, which helps assess how well your body is balancing acidity and alkalinity (acid-base balance).

Quick summary

["Your blood’s CO₂ levels help doctors check for conditions like respiratory issues or metabolic disorders."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
60789-5
Short code
CO2 gas del dur case Vol Gas DS
Synonyms
CO2 gas del dur case Vol Gas DS
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Ref low
22
Ref high
28
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
CPT
82374
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What Does This Test Measure?

Total carbon dioxide (CO₂) in your blood includes both dissolved CO₂ and bicarbonate (HCO₃⁻), which are key components of your body’s acid-base balance. This test helps evaluate how efficiently your lungs remove CO₂ and how your kidneys adjust bicarbonate levels to maintain normal pH.

Why Might You Need This Test?

Doctors may order this test if you have symptoms like shortness of breath, chest pain, or fatigue, which could indicate problems with your lungs or kidneys. It’s also used during monitoring for conditions like heart failure, kidney disease, or severe infections.

Sample Collection and Preparation

This test requires a blood sample drawn from a vein, usually in your arm. The blood is analyzed immediately or sent to a lab to measure total CO₂ levels, often as part of a broader blood gas panel that also checks oxygen and pH levels.

What Are Common Results and Interpretation?

Results are typically reported alongside blood pH and oxygen levels to determine whether your acid-base balance is normal or if adjustments are needed. Elevated CO₂ levels may suggest respiratory issues, while low levels could indicate metabolic problems or overbreathing.

Reference range

Adult: 22-28 mmol/LN/A

Specimen: serum

No special preparation usually required. Stay well hydrated. Inform your healthcare provider of all medications and supplements you are taking.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

Clinical Significance

Short name

Total CO₂ (Blood Gas)

Frequently asked questions

How often will I need this test?
This test is often performed as part of a blood gas analysis, which may be done periodically if you have chronic conditions like COPD, kidney disease, or heart failure. Your doctor will determine how frequently you need it based on your health status and symptoms.
What do my results mean if they’re outside of normal ranges?
If your results are abnormal, your doctor may investigate potential causes such as lung disorders (e.g., asthma, pneumonia), kidney problems, or metabolic conditions. They may also recommend further tests or treatments to address imbalances.
Can I prepare for this test in any special way?
No special preparation is needed for this test. However, if you’re on medications that affect breathing or acid-base balance, let your healthcare provider know before the test.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy