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Serum or plasma concentration of cocaine metabolites (qualitative or semi-quantitative screening)

Published: August 9, 2026Updated: August 16, 2026

This test detects the presence of cocaine and its active metabolites in your blood or plasma, often used to screen for recent drug use.

Quick summary

["Helps identify exposure to cocaine, which may be important for medical or legal reasons."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
55530-0
Short code
Cocaethylene SerPl-sCnc
Synonyms
Cocaethylene SerPl-sCnc
Category
chemistry
Sample
serum
Container
Red-top tube (SST)
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Specimen volume
5 mL
Stability
Room temperature: 4h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
500
Lipemia max
1000
Icterus max
500
TAT
4–24 hours
Order
routine

What This Test Measures

The test looks for specific chemicals produced when cocaine breaks down in your body. These include benzoylecgonine, norcocaine, and other metabolites. A positive result suggests recent cocaine use, though it may not indicate the exact amount or timing.

Why It’s Done

Healthcare providers may order this test if you’ve been exposed to cocaine, if symptoms like confusion, rapid heartbeat, or seizures are present, or if you’re suspected of drug use in a medical or legal context.

Sample Collection and Processing

Blood is drawn from a vein, and the serum or plasma is analyzed using an immunoassay method to detect cocaine metabolites. The test can be qualitative (yes/no) or semi-quantitative (approximate levels).

What to Expect Before the Test

No special preparation is usually needed, but inform your doctor about any medications you’re taking or recent medical conditions. Avoid alcohol or caffeine before the test if instructed.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

A positive result strongly suggests recent cocaine use but does not confirm abuse or dependence. It may help diagnose complications like cocaine-induced heart problems, seizures, or other acute effects. Negative results rule out recent exposure but do not guarantee long-term absence of use.

Short name

Cocaine metabolite screen (serum/plasma)

Frequently asked questions

How long does it take to get results?
Results are typically available within 24 to 48 hours, depending on lab processing times. Follow-up with your healthcare provider if you have questions about the results.
Can I drink water before the blood draw?
Yes, you can drink water before the blood draw unless your doctor specifies otherwise. Avoid excessive fluids that might dilute the sample.
Will this test show if I’ve used cocaine long-term?
No, this test primarily detects recent exposure (within hours to days). Long-term use may require additional testing or urine screens, which can detect metabolites for longer periods.
  1. 1
    MedlinePlus — Laboratory TestsSource
  2. 2
    Lab Tests OnlineSource
  3. 3
    Mayo Clinic — Tests & ProceduresSource

Click any link to access the full source. PubMed Central (PMC) links provide free full-text access.

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy