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Cocaethylene, Urine, Qualitative Screen

Published: August 9, 2026Updated: August 16, 2026

This test screens a urine sample for cocaethylene, a substance formed in the body when alcohol and cocaine are used together. It is used to detect recent combined alcohol and cocaine exposure.

Quick summary

["A positive cocaethylene result indicates that cocaine and alcohol were likely used together, since cocaethylene forms only when both are present."]

Medically reviewed by WellAlly Editorial TeamLast reviewed August 16, 2026Editorial policy

Key facts at a glance

LOINC
19405-0
Short code
Cocaethylene Ur Ql Scn
Synonyms
Cocaethylene Ur Ql Scn
Category
chemistry
Sample
urine
Container
Sterile urine container
Units
N/A
Fasting
false
Population
adult
Sex
all
Age range
18–65 years
Method
screen
Specimen volume
10 mL
Stability
Room temperature: 2h, Refrigerated: 24h, Frozen: 7d
Hemolysis max
0
Lipemia max
0
Icterus max
0
TAT
4–24 hours
Order
routine

What Is Cocaethylene

Cocaethylene is a compound that the body produces when cocaine and alcohol are consumed at the same time. It is not present in either substance alone, so its detection is considered a marker of combined use. It is chemically related to cocaine and can be detected in urine after such combined exposure.

How the Test Works

A urine sample is collected and analyzed with a screening method designed to detect the presence of cocaethylene. Screening tests give a preliminary result, and a positive screen may be followed by a more specific confirmatory method to verify the finding. The test is qualitative, meaning it reports whether cocaethylene is detected rather than an exact amount.

What a Positive Result Means

A positive result suggests that cocaine and alcohol were used together within the detection window of the test. Because results can be affected by factors such as how recently substances were used and how the sample was handled, positive screens are typically confirmed with a second, more definitive method before being acted upon.

What a Negative Result Means

A negative result means cocaethylene was not detected in the sample at the test's level of detection. This generally indicates no recent combined alcohol and cocaine use, but it does not rule out use that occurred outside the detection window or use of one substance without the other.

Clinical interpretation

How abnormal results are interpreted and what conditions they suggest.

◆Associated findings1

Short name

Cocaethylene Urine Screen

Frequently asked questions

Can cocaethylene be detected if only cocaine was used?
No. Cocaethylene forms only when the body processes cocaine in the presence of alcohol, so it is not expected to appear after cocaine use alone. Its detection is considered evidence of combined exposure.
How long after use can cocaethylene be found in urine?
Detection depends on the amount used, individual metabolism, and fluid intake, so there is no single fixed window. In general, markers of cocaine-related exposure are detectable in urine for a limited number of days after use, and your laboratory can advise on expected detection based on the specific method used.
Does a screening result need confirmation?
Often, yes. Screening tests are preliminary and can produce false results in some situations, so a positive screen is commonly verified with a more specific confirmatory test before any conclusions are drawn. Your care team can explain what follow-up testing, if any, is appropriate.
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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 16, 2026. · Read our editorial policy